Increase in Infection Rates in Patients With Cardiac Electrophysiological Devices

by Kathy Jones on  August 23, 2011 at 7:56 PM Heart Disease News
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Patients in the United States who receive cardiac electrophysiological devices (CIEDs), including permanent pacemakers and implantable cardioverter-defibrillators (ICDs) are now at greater risk of contracting an infection over the life span of the device, new research from the Jefferson Heart Institute shows.
 Increase in Infection Rates in Patients With Cardiac Electrophysiological Devices
Increase in Infection Rates in Patients With Cardiac Electrophysiological Devices

Jefferson, in collaboration with researchers from Drexel University School of Biomedical Engineering and engineering and consulting firm Exponent, analyzed data from the Nationwide Inpatient Sample—a national database of hospital discharge records—from 1993-2008 and found a significant increase in CIED-related infections. Their findings are published in the August 30 issue of the Journal of the American College of Cardiology.

Their analysis found that the annual incidence of CIED-related infection increased by 210 percent over the 16-year period studied.

Further analysis showed a jump in infections after 2004, directly correlating with an increase in four major comorbidities: renal failure, respiratory failure, heart failure and diabetes.

"We believe the growing number of clinical comorbidities in this patient population plays a large role in the increase in infections associated with CIEDs," said Arnold J. Greenspon, M.D., professor of medicine at Jefferson Medical College of Thomas Jefferson University, director of Cardiac Electrophysiology at Thomas Jefferson University Hospital, and lead author of the study. "The patients are sicker, which may place them at higher risk for infection." The highest infection rates occurred in white males over 65.

Pacemakers and ICDs are important in regulating the electrical signaling to the heart. Pacemakers help to speed up a slow heart rhythm (bradycardia) whereas ICDs help to slow down rapid heart rhythm (tachycardia), a potentially life-threatening condition.

The study showed a 96 percent increase in CIED implantation, mostly due to a marked increase in the use of ICDs. "The expanding indications for ICD implantation may have contributed to the rise in infections since many of these patients have multiple medical co-morbidities," added Dr. Greenspon.

"The number of Americans receiving pacemakers and defibrillators has dramatically increased. This analysis shows that the infection risk associated with these devices has, unfortunately, increased as well," said Greenspon. A better understanding of the risk factors for infection will improve patient care and, hopefully, reduce the prolonged hospital stays that often result.

Rising CIED infection rates also have economic implications for hospitals, as these patients require prolonged hospital stays which are associated with increased costs.

Further investigation into the risk factors that predict CIED infection or therapies to mitigate this issue is warranted.

Source: Eurekalert

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