Several studies have pointed out that lipid peroxidation activates collagen production in fibroblasts and hepatic stellate cells (HSC), and has a significant role in the development of liver fibrosis.
Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis and alcohol induced liver fibrosis were reported in many studies. However, the hepatoprotective effect of green tea in dimethylnitrosamine (DMN)-induced models has not been studied.
MRI Development Yields Breakthrough in Diagnosis of Liver Fibrosis
A new technique for measuring the hardness or elasticity of the liver has been developed by Mayo Clinic researchers using magnetic resonance imaging (MRI)
A new technique for measuring the hardness or elasticity of the liver has been developed by Mayo Clinic researchers using magnetic resonance imaging (MRI)
The results showed GT administration prevented the development of hepatic fibrosis in the rat model of DMN-induced liver fibrosis. These results were confirmed both by liver histology and by quantitative measurement of hepatic hydroxyproline content, a marker of liver collagen deposition. Accordingly, inhibition of proliferation, reduced collagen deposition, and type 1 collagen expression were observed in activated HSC-T6 cells following GT treatment. These results imply that GT reduced the proliferation of activated HSC and down regulated the collagen content and expression of collagen type 1, thereby ameliorating hepatic fibrosis.
The researchers drew a conclusion that green tea may protect liver cells and reduce the deposition of collagen fibers in the liver. Green tea provides a safe and effective strategy for improving hepatic fibrosis.
New Study may Pave Way for Cure of Liver Fibrosis
A study on mice has shown that fibrosis in the liver can not only be stopped but also reverse some of the cell damage that has already occurred
A study on mice has shown that fibrosis in the liver can not only be stopped but also reverse some of the cell damage that has already occurred
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Breakthrough in Treating Irreversible Liver Cirrhosis
More recent studies reveal that cellular senescence helps protect against the formation of tumors and aids in the response to certain anticancer agents.
More recent studies reveal that cellular senescence helps protect against the formation of tumors and aids in the response to certain anticancer agents.
Scientists Look for Non-invasive Ways to Assess Liver Disease
Two new studies have tested non-invasive alternatives to liver biopsy, in order to examine live diseases like liver fibrosis or cirrhosis.
Two new studies have tested non-invasive alternatives to liver biopsy, in order to examine live diseases like liver fibrosis or cirrhosis.
