Every Parent's Nightmare: Study Explains "cot Death Syndrome"

Doctors have long been baffled by an inexplicable syndrome known as sudden infant cot death. Now, finally, European scientists have shed new light on the causes of the devastating Sudden Infant Death Syndrome, according to a study published on Thursday.

The syndrome, which strikes fear into every parent’s heart, affects seemingly healthy babies aged between a month to a year, and is main cause of death among infants of that age in developed nations.

Sudden Infant Death Syndrome - Overview
Sudden Infant Death Syndrome is death of a baby, under one year of age that occurs in sleep and cannot be explained.

Now researchers at the European Molecular Biology Laboratory in Italy have revealed that an imbalance of the neuronal signal, serotonin, in the brainstem caused sudden death in mice, according to the study in Science magazine.

The brainstem, which is at the base of the brain and joins to the spinal cord, coordinates many of the body’s vital functions such as the cardiovascular and respiratory systems.

The scientists modified serotonin systems in mice seeking to understand the role of the molecule on transmitting neuron signals in the brainstem. Victims of Sudden Infant Death Syndrome (SIDS) have shown alterations in those brainstem neurons that communicate using the signalling molecule serotonin.

Increased Risk of SIDS If Newborns are Overheated
Researchers at the University of Calgary have found that thermal stress or an increased ambient temperature can lead to a greater risk of Sudden Infant Death Syndrome (SIDS).

"At first sight the mice were normal. But then they suffered sporadic and unpredictable drops in heart rate and body temperature," said scientist Cornelius Gross.

"More than half of the mice eventually died of these crises during a restricted period of early life. It was at that point that we thought it might have something to do with SIDS."

Development Milestone
Medindia offers a milestone chart for the growing child, by which we can determine the activities of the baby at various stages of the growth.

Until now it had remained unclear how changes in serotonin signalling in the brainstem could be involved in cot deaths.

The findings showed that deficits in serotonin signalling in the brainstem can lead to sudden death and support the idea that a congenital serotonin defect could play a critical role in SIDS.

Babies "Cot" Dead - Why?
Dundee University researchers seem to know what makes certain babies prone to SIDS and serious health ailments.

"We hope the mouse model will help identify risk factors for SIDS," said researcher Enrica Audero.

"One open question is whether like in SIDS, the animals die during sleep and whether we can identify which mice will die by looking at their heart rate or body temperature before the crisis. Ultimately, we hope it will give new ideas to doctors about how to diagnose babies at risk for SIDS."

Source-AFP
TAN/L