Antioxidant Protein Promotes Atherosclerosis

by Sheela Philomena on  January 12, 2011 at 3:23 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

Researchers from University of California have recently discovered that a protein Nrf2, plays a vital role in some antioxidant therapies and also promotes atherosclerosis - clogging of arteries. Physicians could soon be able to point out why some antioxidant therapies are not yielding the desired effects. br>
The protein, Nrf2, has been thought to be an important drug-therapy target for diseases such as cancer because it can induce chemo-preventive activity, leading to the release of numerous antioxidant and anti-inflammatory genes and enzymes.
 Antioxidant Protein Promotes Atherosclerosis
Antioxidant Protein Promotes Atherosclerosis

Earlier, researchers had reasoned that Nrf2, with its potent ability to boost antioxidants, might also be useful in combating the cell and tissue damage, or oxidation that leads to atherosclerosis.

However, UCLA scientists found that while Nrf2 boosted antioxidant properties in an animal model, it also increased the development of atherosclerosis by raising plasma cholesterol levels and cholesterol content in the liver.

According to them, this is the first study to document these additional effects on cholesterol metabolism in tandem with plaque formation in the arteries.

"The atherosclerosis-producing factors were greater than the antioxidant benefits. The development of novel antioxidant therapies is quite important, and this research may help shed light on why treatments affecting this protein may not be as effective as we thought," said principal investigator Jesus Araujo.

For the study, the team isolated and identified Nrf2's actions by looking at what would happen in mice that were specially bred without the protein.

They found that male mice without Nrf2 not only had decreased levels of antioxidants, but also exhibited a 53 percent reduction in atherosclerotic plaques in the aorta, compared with normal animals.

Mice with only half Nrf2 protein exhibited the same degree of plaque formation as normal animals.

They also found that the mice without any Nrf2 had lower levels of total cholesterol in the blood and lower amounts of cholesterol in the liver.

The protein deficiency also led to reduced expression of the genes involved in synthesizing and storing fat and regulating glucose in the liver, which are part of the process of manufacturing cholesterol.

In addition, the researchers found that most of the effects of Nrf2 were more highly prevalent in the male mice.

The study is published in the current issue of the journal Arteriosclerosis, Thrombosis and Vascular Biology.

Source: ANI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Heart Attack Food Additives Cholesterol - The Enigma Chemical Herbs and Antioxidants Mint It All! Bael - The Ultimate Medicinal Summer Fruit Diet and Nutrition Tips for Athletes Health Benefits of Kiwi Fruit Atherosclerosis 

News A - Z


News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive