A new study has found that a majority of depressed people do not get relief from antidepressants because these drugs have been oversimplified and treat depression in a generic manner instead of being given for specific types of the condition.
Eva Redei, psychiatry professor at Northwestern University Feinberg School of Medicine (NUFSM) and colleagues exposed four genetically different strains of rats to chronic depression.
The team then examined the genes in brain regions and found they had increased or decreased due to stress. "This finding is clear evidence that at least in an animal model, chronic stress does not cause the same molecular changes as depression does," Redei said. "This is a huge study and statistically powerful. This research opens up new routes to develop new antidepressants that may be more effective. There hasn't been an antidepressant based on a novel concept in 20 years."
The study was presented at the Neuroscience 2009 conference recently.