AIDS Virus Prevented from Entering Cells by Engineered Protein

A new protein that prevents AIDS virus from entering cells has been engineered by scientists. The protein fragment is based on a naturally occurring protein called RANTES, which is part of the body's immune system.

RANTES naturally defends the body against HIV/AIDS, but cannot be used as a drug or drug candidate because it has several other biological effects, which could cause harmful inflammation.

After examining the precise molecular structure of the RANTES protein, the researchers discovered that only a small fragment of the RANTES protein is actually responsible for blocking HIV entry into cells.

From there, they dissected the desired section of the RANTES protein and worked to stabilize it without compromising its protective effects.

After several sequential steps of molecular refinement and some virtual modeling, the researchers created a peptide with very high potency against HIV, with possible benefits for treating inflammatory diseases such as arthritis and lupus, as well as the prevention of transplant rejection.

"This is science fiction made reality. These researchers took a protein apart and removed the portion that causes harm, then stabilized and modified the section that has a therapeutic effect," said Gerald Weissmann, Editor-in-Chief of The FASEB Journal.

Advertisement

"Not only is this good news for people with AIDS, but also it's good news for all of us as this research paves the way for similar work for many, many other illnesses," he added.

The study is published in the April 2011 issue of The FASEB Journal.

Advertisement

Source-ANI