New 3D-printed scaffold which mimics the gradient structure of cartilage to bone may someday help heal common sports-related injuries.

‘New 3-D-printed artificial tissues which mimic the gradient structure of cartilage to bone may someday help heal common sports-related injuries.’

Injuries to these bones, from small cracks to pieces that break off, can be painful and often stop athletes' careers in their tracks. Osteochondral injuries can also lead to disabling arthritis.




The gradient nature of cartilage-into-bone and its porosity have made it difficult to reproduce in the lab, but Rice scientists led by bioengineer Antonios Mikos and graduate student Sean Bittner have used 3D printing to fabricate what they believe will eventually be a suitable material for implantation.
"Athletes are disproportionately affected by these injuries, but they can affect everybody," said Bittner, a third-year bioengineering graduate student at Rice, a National Science Foundation fellow and lead author of the paper. "I think this will be a powerful tool to help people with common sports injuries."
The key is mimicking tissue that turns gradually from cartilage (chondral tissue) at the surface to bone (osteo) underneath. The Biomaterials Lab at Rice printed a scaffold with custom mixtures of a polymer for the former and a ceramic for the latter with imbedded pores that would allow the patient's own cells and blood vessels to infiltrate the implant, eventually allowing it to become part of the natural bone and cartilage.
"For the most part, the composition will be the same from patient to patient," Bittner said. "There's porosity included so vasculature can grow in from the native bone. We don't have to fabricate the blood vessels ourselves."
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Mikos said the collaboration is a great early success for the Center for Engineering Complex Tissues (CECT), a National Institutes of Health center at Maryland, Rice and the Wake Forest School of Medicine developing bioprinting tools to address basic scientific questions and translate new knowledge into clinical practice.
Source-Eurekalert