12 Hidden Facts About Hemophilia B

Hemophilia B is a rare single gene disorder. It is also known as Factor IX deficiency or Christmas disease. This disorder tends to run in families for generations as it only affects males because it is X- linked disorder (1^✔ ✔Trusted Source
Hemophilia B: Medlineplus

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Due to the deficiency of an important clotting factor called factor IX, blood clot formation following an injury may not be proper, and so following an accident, hemophiliacs can suffer from excessive bleeding, as it takes longer to heal, in comparison to normal individuals.

Facts About Hemophilia B

1. Hemophilia B is thought to be named after Stephen Christmas, who was first diagnosed with this disease in 1952 (2^✔ ✔Trusted Source
   Factor IX deficiency (Christmas disease)
   
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2. Hemophilia B is inherited as an X-linked recessive disorder, where only the males are affected, and females act as carriers of the disease (3^✔ ✔Trusted Source
   Hemophilia B
   
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3. Worldwide, Hemophilia B is considered to be seven times less common than Hemophilia A which occurs in about 1 in 25,000 and 1 in 30,000–60,000 boys in the US and India (2^✔ ✔Trusted Source
   Factor IX deficiency (Christmas disease)
   
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4. It is estimated that currently, around 30,000 - 33,000 men in the United States are suffering from this disorder (4^✔ ✔Trusted Source
   A New Study of Hemophilia Occurrence Finds Many More Cases in the United States
   
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5. In the United States, it is estimated that Hemophilia A is four times more common than Hemophilia B and almost half of those who are affected have a severe form of this disorder (5^✔ ✔Trusted Source
   Evaluation of CDC's Hemophilia Surveillance Program - Universal Data Collection (1998-2011) and Community Counts (2011-2019), United States
   
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6. Hemophilia can affect people of all racial and ethnic groups (6^✔ ✔Trusted Source
   What is Hemophilia?
   
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7. Hemophilia B is sometimes also referred to as 'The Royal Disease', because it had affected the royal families of England, Germany, Russia and Spain in the 19th and 20th centuries (7^✔ ✔Trusted Source
   Hemophilia - B
   
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8. Queen Victoria who ruled England between 1837 and 1901, is said to have been a carrier of Hemophilia B (8^✔ ✔Trusted Source
   Hemophilia
   
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9. The global incidence of Hemophilia is estimated to be more than 400,000, and it is estimated that around 75% of people with hemophilia still don’t have access to adequate treatment (9^✔ ✔Trusted Source
   Haemophilia: provision of factors and novel therapies: World Federation of Hemophilia goals and achievements
   
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10. There is no cure for the disease, and the standard treatment of factor IX concentrates can be effective to overcome the deficiency.
11. About one third of hemophilia cases occur in families with no previous history of the disorder (10^✔ ✔Trusted Source
    Clinical and laboratory approaches to hemophilia a
    
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12. Hemophilia can occur in women, but it is less common (11^✔ ✔Trusted Source
    Women Can Have Hemophilia, Too
    
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