Most commonly used herbicide- paraquat and its oxidative stress mechanism were studied in connection with the development of Parkinson's disease by a research team. This study, which utilized the CRISPR-Cas9 gene-editing tool, serves as a proof-of-concept for using genetic screens to investigate the biology of oxidative stress. Certain people with genetic mutations could have high levels of these POR, ATP7A and SLC45A4 genes. These genes could help identify people who are vulnerable to paraquat associated Parkinson's disease.
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