Promising Target for Treatment of Psoriasis is Safe

A group of inflammatory proteins called ''IL-36'' play a significant role in the development of psoriasis and can, in theory, be blocked without posing a risk to patients. Evidence has emerged during the past several years pointing to a key role for IL-36 in psoriasis. Overexpression of IL-36 in mouse skin leads to a disease quite similar to human plaque psoriasis, and inhibition of IL-36 in human psoriatic skin ameliorates the inflammation.