Two research studies being presented during the 29th Annual ASE Scientific Sessions use echocardiography to study
patients across the human life span. One study assessed heart failure risks with reduced ejection fraction in young middle-aged
and elderly patients while the other aimed to understand arterial stiffness in newborns of mothers with diabetes.
Researchers at Jacobi Medical Center Montefiore Medical Center and Albert Einstein College of Medicine sought to better understand
heart failure caused by reduced heart pump function and measured by echocardiography (heart ultrasound) as “ejection fraction” in
over 20000 racially diverse urban patients stratified by age and socioeconomics over 16 years. As expected there were
proportionally fewer younger (18-39 years old) people with heart failure. They were more likely to be male black and poor with
larger weaker hearts but their hospital readmission rates were lower and survival was better than in the older patients. Dan
Leslie Li MD Jacobi Medical Center Department of Internal Medicine Albert Einstein College of Medicine Bronx NY said with
regard to the study results “Young patients with heart failure living in an indigenous urbane environment are under-studied. We
explored unique clinical characteristics and prognostic determinants in young patients who are mostly racial minorities. Our
research highlights the importance of age-specific preventive and therapeutic interventions for heart failure population with
diverse socioeconomic background.”
Researchers on the study Heart Failure with Reduced Ejection Fraction (HFrEF) in Young Patients Has Unique Clinical and
Sociodemographic Features: An Urban and Multiracial Observation included Dan Leslie Li Ignacio Zepeda Renato Quispe Jacobi
Medical Center Department of Internal Medicine Albert Einstein College of Medicine Bronx NY and Cynthia Taub Montefiore
Medical Center Department of Cardiology Albert Einstein College of Medicine Bronx NY. Dr. Li will present a poster based on this
research on Sunday June 24 2018 at the Gaylord Opryland Resort & Convention Center.
Just a few miles across town at Icahn School of Medicine at Mount Sinai and Bronx Lebanon Hospital Center Bronx NY researchers
explored whether arterial stiffness an ultrasound marker of cardiovascular health of the blood vessels and cardiac function are
altered in the children of diabetic mothers. Seventy-six echocardiograms and carotid - femoral pulse wave velocity studies were
performed serially from birth to two years age in 15 such children and compared to 25 children whose mothers did not have diabetes.
“In this study we found differences in the stiffness of the main blood vessel coming from the heart (aorta) and in the cardiac
global longitudinal strain a sensitive detector of abnormal heart function at two years of age in children of diabetic mothers as
compared to those whose mothers did not have diabetes. Further research is required to determine if maternal diabetes may predispose
to the development of hypertension and heart disease as these children grow into adulthood.” said Aparna Kulkarni MD Icahn School
of Medicine at Mount Sinai Bronx Lebanon Hospital Center Bronx NY.
Researchers on the study Offspring of Mothers with Diabetes Mellitus have Altered Arterial Stiffness into Early Childhood include
Daisy Gonzalez Alejandra Bueno Uzoma Obiaka Seyed M. Mahmoudi and Aparna Kulkarni from Icahn School of Medicine at Mount Sinai
Bronx Lebanon Hospital Center Bronx NY. Ms. Gonzalez will present a poster based on this research on Sunday June 24 2018 at the
Gaylord Opryland Resort & Convention Center.