DUBLIN, Oct. 18, 2018 /PRNewswire/ -- United Neuroscience (UNS), a clinical-stage biotech company pioneering
"We are highly encouraged by the progress of our Alzheimer's vaccine program and remain on track to announce top-line data from our Phase IIa study before the end of the year," said Mei Mei Hu, Chief Executive Officer of United Neuroscience. "Alzheimer's disease is one of the greatest challenges in the world of medicine, and United Neuroscience is committed to developing innovative technologies for this growing patient population."
Ajay Verma, M.D., Ph.D., the company's Chief Medical Officer, added, "We are eager to examine the anti-A? antibody response elicited by the different boosting schedules in our Phase IIa study. The multiple brain MRI and amyloid PET scans included in our study will help us to objectively assess safety and target engagement."
Oral Presentation Details:
Active Anti-amyloid Immunotherapy with UB-311 Vaccine: Design, baseline data and study update of a Phase IIa, Randomized, Double-Blind, Placebo-Controlled, 3-Arm Parallel-Group, Multicenter Study
Presenter: Ajay Verma, M.D., Ph.D., CMO of United NeuroscienceDate: Oct. 25, 2018Time: 9:15 a.m. – 9:30 a.m. CESTLocation: Palau de Catalunya Conference CenterPresentation Number: OC4
About UB-311 in Alzheimer's Disease
Active vaccination of human individuals against A? has yet to be safely and effectively achieved. Other active vaccine efforts have either reported low antibody titers and responder rates or significant safety issues such as T-cell mediated encephalitis. The most advanced Alzheimer's vaccine in all clinical development, UB-311 is currently in a Phase IIa study with top-line results expected by the end of the year. In the Phase I study, UB-311 vaccination safely elevated anti-A? antibodies in all patients with a suggestion of cognitive stabilization. UB-311 is a novel UBITh™ active vaccine targeting the N-terminus of A? that is designed to induce high B-cell specific responses while avoiding T-cell inflammation. UB-311 was shown to generate site-specific antibodies across mice, guinea pigs, macaques and baboons and to reduce A?1–42 oligomers, protofibrils and plaque load in a transgenic mouse model of Alzheimer's disease.
About United Neuroscience
United Neuroscience (UNS) is a clinical-stage biotech company dedicated to the development of best-in-class immunotherapeutics for the brain. A global company headquartered in Dublin, Ireland, with operations in Taiwan and the United States, UNS was founded to address the social and economic burden of Alzheimer's and other neurodegenerative diseases and seeks to rapidly advance candidates into and through clinical trials with the goal of delivering breakthrough treatments to patients. For more information please visit www.unitedneuroscience.com.
Follow UNS on Twitter at https://twitter.com/UNSTechBio and on LinkedIn at https://www.linkedin.com/company/unitedneuroscience.
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SOURCE United Neuroscience
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