The TFOS international Dry Eye WorkShop II (TFOS DEWS II), whose report has been published in the July 2017 issue of theOcular Surface journal, acknowledged that trehalose is an effective ingredient in association with hyaluronic acid for the treatment of dry eye.
According to Professor Benitez del Castillo (Spanish Society of ophthalmology and Ocular Surface Specialist), "the association of hyaluronic acid and trehalose can be considered a significant progress in the treatment of moderate to severe dry eye syndrome, acting at the same time on dry eye disease and its clinical symptoms."
The TFOS DEWS II report is a massive undertaking involving 150 clinical and basic research experts from around the world. They used an evidence-based approach and a process of open communication, dialogue and transparency to achieve a global consensus regarding multiple aspects of dry eye disease.
Dry eye disease is a very common condition, with a prevalence that ranges between 5 and 50% across the world. Prevalence increases with age, especially in women. Symptoms include eye pain, dryness, redness, excessive watering, contact lens discomfort, irritation from wind or smoke, tired eyes, foreign body sensations, blurred vision and photophobia. Dry eye can affect patients' ability to read and drive. It can also sometimes lead to anxiety and depression. Dry eye disease can be caused by a variety of factors such as ageing, wearing contact lenses, environmental aspects (staring at screens, pollution), a person's overall condition (i.e. hormonal changes, menopause), certain medications (anti-acne, certain beta-blockers, oral contraceptives, antihistamines, diuretics and antidepressants) or a patient's medical history (eye lid inflammation, lasik surgery). For Emmanuel Muriaux, Director of R&D innovation at Théa, "the TFOS DEWS II report validates years of research at Théa to offer a safe and effective treatment to the numerous patients who suffer from dry eye disease worldwide."
About Thealoz® Duo*:
Thealoz® Duo is the first association that combines trehalose and hyaluronic acid for the treatment of dry eye disease ; it is a hypotonic formulation. Thealoz® Duo is totally preservative-free and available in multidose dispensers with a membrane filter, that prevents both the risk of toxicity and damage to the ocular surface and microbial contamination. TFOS experts highly recommend in the DEWS II report that patients suffering from dry eye disease avoid the use of ocular lubricants that contain preservatives (especially benzalkonium chloride).
About TFOS and DEWS II:
The Tear Film & Ocular Surface Society (TFOS) is a world leader in eye health education, gathering international scientists, clinicians and industry professionals to understand the composition and regulation of the preocular tear film.
The TFOS international Dry Eye WorkShop II (DEWS II) lasted over two years, and mobilized 12 subcommittees, made up of 150 experts from 23 different countries. Its report contains 10 chapters, covering more than 400 pages. Full report available here
Théa is an independent pharmaceutical company dedicated to ophthalmology. This 150-year-old family business is the world leader for preservative-free eye care products. Théa is based in Clermont-Ferrand (France) and counts almost 1,000 employees across the globe. Théa products are available in more than 70 countries worldwide. http://www.laboratoires-thea.com
*In France, Tunisia and Morocco, Thealoz® Duo is named Théalose®.
 TFOS DEWS II report, The Ocular Surface 15 (2017)
 Necas et al, Hyaluronic acid (hyaluronan): a review, Veterinarni Medicina, 53. 2008 (8): 397-411.
 Jain NK, Roy I. Effect of trehalose on protein structure. Protein Sci. 2009; 18 (1): 24-36.
 Corrales RM, Luo L, Chang EY, Pflugfelder SC. Effects of osmoprotectants on hyperosmolar stress in cultured human corneal epithelial cells. Cornea. 2008; 27 (5): 574-9.
 TFOS DEWS II, Management and Therapy Report, Ocular Surface 2017, 580-634.
 TFOS DEWS II, Epidemiology Report, Ocular Surface 2017, 334-368.
 Miljanovic B, Dana R, Sullivan DA, et al. Impact of dry eye syndrome on vision-related quality of life. Am J Ophthalmol. 2007; 143:409-15
 Li M, Gong L, Sun X, et al. Anxiety and depression in patients with dry eye syndrome. Curr Eye Res. 2011; 36:1-7
SOURCE Laboratoires Théa
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