SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE 11TH ANNUAL NEEDHAM GROWTH STOCK CONFERENCE

SAN DIEGO, CA, Dec. 17, 2008 Senomyx, Inc.(Nasdaq: SNMX), a leading company focused on using proprietary taste receptortechnologies to discover and develop novel flavor ingredients for the food,beverage, and ingredient supply industries, announced today that Kent Snyder,the Company's President and CEO, and John Poyhonen, Senior Vice President,Chief Financial and Business Officer, will present a corporate overview onWednesday, January 7, 2009 at 9:00 a.m. Eastern Time (6:00 a.m. Pacific Time)during the 11th Annual Needham Growth Stock Conference. The conference istaking place at the New York Palace Hotel. During the presentation, Mr. Snyderand Mr. Poyhonen will discuss corporate developments including the Company'spipeline of novel flavor ingredients and its business strategy.

To access the live presentation or a subsequent archived recording, pleaselog onto Senomyx's website at http://www.senomyx.com and click on the"Investor Relations" tab. The archived webcast will be available for 30 daysfollowing the presentation. Please connect to Senomyx's website prior to thestart of the webcast to ensure adequate time to download any software that maybe necessary.

About Senomyx, Inc.

Senomyx is a leading company using proprietary taste receptor technologiesto discover and develop novel flavor ingredients in the savory, sweet, salt,bitter, and cooling areas. Senomyx has entered into product discovery anddevelopment collaborations with seven of the world's foremost food, beverage,and ingredient supply companies: Ajinomoto Co., Inc., Cadbury plc, CampbellSoup Company, The Coca-Cola Company, Firmenich SA, Nestle SA, and Solae.Nestle is currently marketing products that contain one of Senomyx's flavoringredients. For more information, please visit http://www.senomyx.comContact: Gwen Rosenberg Senomyx, Inc. Vice President, Investor Relations & Corporate Communications 858-646-8369 [email protected]

SOURCE Senomyx, Inc.

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