Research Network Based at Duke Clinical Research Institute Awarded up to $102.5M for Work on Antibacterial Resistance

Friday, December 13, 2019 Research News
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The Antibacterial Resistance Leadership Group conducts clinical research to better understand how to diagnose, treat, and prevent antibacterial resistant infections.

DURHAM, N.C., Dec. 13, 2019 /PRNewswire/ -- The Antibacterial Resistance Leadership Group (ARLG), a unique research network for which the Duke Clinical Research Institute (DCRI) acts as a coordinating center, received a federal award worth up to $102.5 million over seven years that will continue the ARLG mission to prioritize, design, and execute clinical research to reduce the public health threat of antibacterial resistance.

The funding, provided by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, supports the mission of the ARLG under award number UM1AI104681.

Antibacterial treatments are becoming less effective, resulting in an urgent threat to public health. A 2019 report from the Centers for Disease Control and Prevention estimates that antibiotic-resistant bacteria infect more than 2.8 million people annually, killing at least 35,000 in the U.S.

The ARLG, which received its inaugural funding from NIAID in 2013, is composed of more than 50 leading experts working together to innovate clinical trial design, inform guidelines, and improve clinical practice in infectious diseases.

The ARLG's research team has collaborations in 19 countries and has initiated more than 40 clinical research studies involving more than 20,000 patients across more than 130 sites. Its three areas of research align with the CDC's antibiotic resistance threats and include:

  • Infections caused by Gram-negative bacteria, such as Escherichia coli;
  • Infections caused by Gram-positive bacteria, such as Staphylococcus aureus; and
  • Diagnostics such as rapid point-of-care tests to detect drug resistance, guide antibacterial therapy, and support clinical trials.
"The renewal support from the NIAID will allow the ARLG to continue its collaborative work to advance science in antibacterial research, and to provide funding opportunities for the next generation of researchers dedicated to addressing this public health threat," said Vance Fowler, M.D., ARLG co-principal investigator, member of the DCRI, and professor of medicine at the Duke University School of Medicine.

"We are delighted to be able to continue to support efforts to fight antibiotic resistance by generating data that is used to inform dosing guidelines and developing diagnostic testing for better detection and timely treatment," Fowler said.

About the Duke Clinical Research Institute The DCRI, part of the Duke University School of Medicine, is the largest academic research organization in the world. Its mission is to develop and share knowledge that improves the care of patients through innovative clinical research. The institute conducts groundbreaking multinational clinical trials, manages major national patient registries, and performs landmark outcomes research. DCRI research spans multiple disciplines, from pediatrics to geriatrics, primary care to subspecialty medicine, and genomics to proteomics. Since 1996, the DCRI has published more than 15,000 scientific papers, which have received more than 760,000 citations in scientific articles. The DCRI also is home to the Duke Databank for Cardiovascular Diseases, the largest and oldest institutional cardiovascular database in the world, which continues to inform clinical decision-making 40 years after its founding.

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SOURCE Duke Clinical Research Institute

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