Reportlinker Adds Monoclonal Antibody Therapies 2007: Competitive Landscape and Pipeline Insight

Friday, November 6, 2009 General News
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NEW YORK, Nov. 5 -- announces that a new market research report is available in its catalogue.

Monoclonal Antibody Therapies 2007: Competitive Landscape and Pipeline Insight

In 2005, the antibodies market was

valued at an estimated US$14 billion, accounting for over 24 percent of the total protein therapeutics market. This share increased substantially since 2001, when it barely surpassed 13 percent. Monoclonal antibody (MAbs) therapies have been posting the fastest growth within the protein therapeutics market. According to the report Monoclonal Antibody Therapies 2007: Competitive Landscape and Pipeline Insight the value of this market is set to reach more than $16 billion in 2006. This growth will continue in the coming years, boosted by a number of new MAbs on the market, new indications for successful medications, and their ability to treat conditions and diseases for which there is great unmet need.

Monoclonal Antibody Therapies 2007 provides an analytically-based overview of the growing market for therapeutic monoclonal antibodies, which represent the largest segment of protein-based therapeutics. An increasing number of biotech companies are investing in the MAbs field, mostly in collaboration with major pharmaceutical companies, to take advantage of this dynamic and growing field.

This report assesses the overall monoclonal antibody market, as part of the wider protein therapeutics industry. Factors influencing their historical and future performance - including manufacturing problems and the impact of future generic competition - are assessed to provide a balanced overview of the market and key products by major therapeutic categories. Finally, the report forecasts likely revenue performance of the most successful products in the next five years, identifying key areas of growth.

Key Features of this report:

Thorough market analysis of global monoclonal antibody sales, segmented by product, company, and geographic region

Financial forecasts for key MAbs on the market as well as promising new MAbs entering the market

Analysis of MAb manufacturing issues and their effect on the financial potential of the therapeutic MAb market

Profiles of key companies involved in the development and marketing of therapeutic MAbs

A review of important happenings in R&D and an evaluation of the upcoming crop of new MAbs

Who should buy this report?

Companies with a need to better understand the monoclonal antibody market and its place in the modern pharmaceutical industry

Companies interested in understanding the impact and implications of product placement, lifecycle management and competition in the monoclonal antibody marketplace

Pharma and biotech companies wishing to identify potential areas for partnerships and collaboration in the monoclonal antibody market 

Table of Contents

1 Methodology, Objectives and Executive Summary

1.1 Report Objectives

1.2 Research Methodology

1.3 Executive Summary

2 Challenges and Issues In the Protein Therapeutics Market

2.1 Pricing

2.2 Drug Delivery

2.3 Manufacturing Capacity

2.4 The Biogeneric Threat

2.4.1 Loss of Patent Protection

2.4.2 High Manufacturing Costs

2.4.3 Lack of Adequate Legislation

2.4.4 Restrictive Cost of Biotech Generics

2.4.5 Biogeneric Landscape

3 Overview of the Monoclonal Antibody Class

3.1 History of MAbs

3.2 The Production of MAbs

3.3 How do Monoclonal Antibodies Work?

3.4 Types of Monoclonal Antibodies

3.4.1 Human Antibodies

3.4.2 Humanized Antibodies (CDR-Grafted)

3.4.3 Chimeric Antibodies

3.4.4 Murine Antibodies

4 Barriers to Successful Treatment with Monoclonal Antibodies

4.1 Human Anti-Mouse Response

4.2 Side Effects

4.3 Nature of Disease

4.4 Manufacturing Capacity Limitations

4.4.1 Manufacturing Costs

4.4.2 Contract Manufacturing as an Alternative

4.4.3 Potential of Transgenic Protein Production

5 Therapeutic Applications for Monoclonal Antibodies

5.1 Cancer

5.1.1 Rituxan (rituxumab)

5.1.2 Herceptin (trastuzumab)

5.1.3 Campath (alemtuzumab)

5.1.4 Mylotarg (gemtuzumab ozogamicin)

5.1.5 Zevalin (ibritumomab tiuxetan)

5.1.6 Erbitux (cetuximab)

5.1.7 Bexxar (tositumomab) Avastin (bevacizumab)

5.2 Autoimmune/Inflammatory Diseases

5.2.1 Rheumatoid Arthritis Remicade (infliximab) Humira (adalimumab)

5.2.2 Inflammatory Bowel Disease Remicade (infliximab)

5.2.3 Multiple Sclerosis Tysabri (natalizumab)

5.2.4 Psoriasis Raptiva (efalizumab)

5.2.5 Asthma Xolair

5.2.6 Age-Related Macular Degeneration (AMD) Lucentis (ranibizumab)

5.2.7 Transplant Rejection Simulect (basiliximab) Zenapax (daclizumab) Orthoclone OKT-3 (muromonab CD3)

5.2.8 Other Conditions Percutaneous coronary intervention (PCI) ReoPro (abciximab) Lower Respiratory Tract Disease Synagis (palivizumab)

6 Market Analysis

6.1 Commercial Market Size

6.2 Segmentation by Therapeutic Category

6.2.1 Cancer

6.2.2 Autoimmune/Inflammatory

6.3 Market Share by Country/Region

6.4 Key Product Sales

6.5 Market Share by Company

6.6 Market Outlook

6.6.1 Drivers

6.6.2 Restraints

6.6.3 Financial Forecast

7 MAbs Innovation

7.1 MAb Structure Innovation

7.1.1 Immunogenicity

7.1.2 Effector Function

7.1.3 Antibody Size and Structure

7.1.4 Affinity

7.2 MAbs Drug Delivery Innovation

7.2.1 Inhaled MAb Delivery

7.2.2 Oral MAb Delivery

7.3 MAbs Technology Innovation

8 Emerging Monoclonal Antibody Therapies

8.1 Cancer

8.1.1 ABX-EGF (panitumumab)

8.1.2 Cotara (TNT-1)

8.1.3 Rencarex (WX-G250)

8.1.4 OvaRex

8.1.5 MDX-010

8.1.6 HuMax-CD4

8.1.7 Avastin

8.1.8 HuMax-CD20

823 Autoimmune/Inflammatory

8.2.1 Humira

8.2.2 Rituxan

8.2.3 Actemra (tocilizumab)

8.2.4 HuMax-CD20

8.2.5 Campath

8.2.6 CDP 870 (certolizumab pegol)

8.2.7 Remicade

8.2.8 Tysabri

8.2.9 AMG 412

8.2.10 LymphoCyde

8.2.11 SB 240563

8.2.12 MLN 1202

8.2.13 ABT 875

8.2.14 CNTO 148

8.3 Other Conditions

8.3.1 Segard

8.3.2 Anti-C5 Antibody

8.3.3 5G1.1

8.3.4 Aurograb

8.3.5 AMG 162

9 Key Companies in the MAbs Market

9.1 Abbott Laboratories

9.2 Biogen Idec

9.3 Cambridge Antibody Technology

9.4 Chugai Pharmaceutical

9.5 Dyax

9.6 Elan Corporation

9.7 Genentech

9.8 Genmab

9.9 Genzyme

9.10 Human Genome Sciences

9.11 ImClone

9.12 Immunomedics

9.13 InNexus Biotechology

9.14 Johnson & Johnson

9.15 Medarex

9.16 MedImmune

9.17 PDL Biopharma

9.18 Raven Biotechnologies

9.19 Regeneron Pharmaceuticals

9.20 Roche

9.21 Seattle Genetics

9.22 Xencor

9.23 Xoma



Table 3.1 Mammalian Antibody Types

Table 4.1 Principal Methods of Creating Transgenic Animals

Table 4.2 Pros and Cons of Transgenic Plants

Table 4.3 Companies Involved in the Field of Transgenic Protein Technology

Table 5.1 Monoclonal Antibody Therapies on the Market 2006

Table 5.2 Monoclonal Antibodies on the Market for the Treatment of Cancer

Table 5.3 Monoclonal Antibodies on the Market for the Treatment of Autoimmune/Inflammatory Conditions

Table 5.4 Description of IBD

Table 5.5 Types of MS

Table 5.6 Types of Transplant Rejection

Table 5.7 Antibodies Used to Prevent Transplant Rejection

Table 6.1 Leading Monoclonal Antibody Products, by Sales 2000-2006 (US$mn)

Table 6.2 US Sales of Monoclonal Antibodies, Cancer Indications 2000-2006 (US$mn)

Table 6.3 Monoclonal Antibody Sales, Autoimmune/Inflammatory Indications, 1999-2006 (US$mn)

Table 6.4 Monoclonal Antibody Market Share (2005), by Country/Region

Table 6.5 Global Sales of Herceptin 2000-2006 (US$mn)

Table 6.6 Global Sales of Avastin 2004-2006 (US$mn)

Table 6.7 Global Sales of Rituxan 2003-2006 (US$mn)

Table 6.8 Global Sales of Humira 2003-2006 (US$mn)

Table 6.9 Global Sales of Remicade 2000-2006 (US$mn)

Table 6.10 Global Sales of Raptiva 2003-2006 (US$mn)

Table 6.11 Global Sales of Xolair 2003-2006 (US$mn)

Table 6.12 Financial Forecast for the Monoclonal Antibody Market 2005-2010 (US$bn)

Table 6.13 Forecast Sales of Leading Monoclonal Antibody Products 2005-2010 (US$mn)

Table 7.1 Key Areas of MAb R&D Efforts

Table 7.2 Targeted Therapy Approaches

Table 8.1 Avastin Status in Clinical Trials

Table 8.2 Types of ACR Response Criteria

Table 9.1 Biogen Idec's Mab Pipeline

Table 9.2 CAT's Clinical Pipeline

Table 9.3 Immunomedics' Key Product Pipeline

Table 9.4 Medarex's MAb Pipeline

Table 9.5 Roche's Mab Products


Graph 6.1 Leading Monoclonal Antibody Products by 2005 Sales (US$mn)

Graph 6.2 Monoclonal Antibody Market Share by Therapeutic Category (2005)

Graph 6.3 Annual Percentage Growth of US Sales of Monoclonal Antibodies, Cancer Indications 2000-2005

Graph 6.4 Annual Growth of Monoclonal Antibody Sales, Autoimmune/Inflammatory Indications, 2001-2005

Graph 6.5 Monoclonal Antibody Market Share, US vs Rest of World

Graph 6.6 Monoclonal Antibody Market Share, by Top Five Products 2005

Graph 6.7 Leaders in the Monoclonal Antibody Therapy Market, 2005 Market Share

Graph 6.9 Forecast of Annual Percentage Sales Growth of Leading Monoclonal Antibody Products 2005-2010

Graph 6.8 Total Forecast Sales of Leading Monoclonal Antibody Products 2005-2010 (US$mn)


Figure 7.1 Modified Antibodies

To order this report:

Monoclonal Antibody Therapies 2007: Competitive Landscape and Pipeline Insight

More market research reports here!

SOURCE Reportlinker

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