Rare Disease Repurposing Datathon from Elsevier and The Pistoia Alliance Reveals New Candidates for Potential Treatment of Chronic Pancreatitis

Thursday, February 28, 2019 General News
Email Print This Page Comment bookmark
Font : A-A+

Participants used the AI environment created by Elsevier's Entellect platform in collaborative effort to discover potential treatments

Target

Candidate drug

Cathepsin B is in humans encoded by the CTSB gene. Cathepsin B belongs to a family of lysosomal cysteine proteases and plays an important role in intracellular proteolysis.

Lacosamide is a medication for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.

The CFTR gene provides instructions for making a protein called the cystic fibrosis transmembrane conductance regulator. This protein functions as a channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes.

Dapsone, is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is a second-line medication for the treatment and prevention of pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function.

Tumor necrosis factor alpha (TNF-a) is a cell signaling protein (cytokine) involved in systemic inflammation.

Rolipram is a blood-brain-barrier permeable, phosphodiesterase type IV inhibitor that reduces breakdown of cAMP and has various neuroprotective properties including anti-inflammatory actions and inhibitory effects on excitatory amino acid toxicity.

Tumor necrosis factor alpha (TNF-a) is a cell signaling protein (cytokine) involved in systemic inflammation.

Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders and cancers.



Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
I agree to the terms and conditions

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Press Release Category

Press Release Archive

Stay Connected

  • Available on the Android Market
  • Available on the App Store