Target | Candidate drug |
Cathepsin B is in humans encoded by the CTSB gene. Cathepsin B belongs to a family of lysosomal cysteine proteases and plays an important role in intracellular proteolysis. | Lacosamide is a medication for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. |
The CFTR gene provides instructions for making a protein called the cystic fibrosis transmembrane conductance regulator. This protein functions as a channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes. | Dapsone, is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is a second-line medication for the treatment and prevention of pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function. |
Tumor necrosis factor alpha (TNF-a) is a cell signaling protein (cytokine) involved in systemic inflammation. | Rolipram is a blood-brain-barrier permeable, phosphodiesterase type IV inhibitor that reduces breakdown of cAMP and has various neuroprotective properties including anti-inflammatory actions and inhibitory effects on excitatory amino acid toxicity. |
Tumor necrosis factor alpha (TNF-a) is a cell signaling protein (cytokine) involved in systemic inflammation. | Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders and cancers. |
