Nordic Nanovector to Present Preclinical Data Highlighting the Anti-tumor Effect of Humalutin® in Three Lymphoma Models at AACR 2018

Thursday, March 15, 2018 Cancer News
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OSLO, Norway, March 15 2018 /PRNewswire/ --Nordic Nanovector ASA (OSE: NANO) announces that it will present a poster reporting

the anti-tumour effect of Humalutin® (177Lu-conjugated humanized anti-CD37 antibody, 177Lu-NNV003) in preclinical models of non-Hodgkin's lymphoma (NHL) at the American Association of Cancer Research (AACR) Annual Meeting 2018. The meeting takes place
from 14-18 April in Chicago, USA. 

The preclinical data to be presented, described in an abstract published yesterday (link), demonstrate that:

In tumour cell lines:

  • The unlabelled anti-CD37 antibody (NNV003) kills tumour cells mainly through an immunological process called antibody dependent cellular cytotoxicity
  • Humalutin® (177Lu-NNV003) was found to inhibit tumour cell growth.

In preclinical lymphoma models:

  • Humalutin® has shown significant tumour uptake and demonstrated an anti-tumour effect in all three NHL models (mantle cell lymphoma, diffuse large B-cell lymphoma and chronic lymphocytic leukaemia).

Jostein Dahle, Chief Scientific Officer commented: "The data is important for Nordic Nanovector as they provide an early demonstration of the potential that Humalutin® has for treating different types of NHL. These encouraging data provide further support to the planned clinical development of Humalutin®, for which Nordic Nanovector expects to launch a Phase I study in NHL in the second half of 2018."

Details for the poster presentation are as follows:

Poster Title: In vitro and in vivo evaluation of the beta-emitting lutetium-177 labeled anti-CD37 antibody radionuclide conjugate 177Lu-NNV003 in DLBCL, CLL and MCL models Session Date and Time: Sunday 15 April 2018, 1:00 PM - 5:00 PM (Central Time) Location: McCormick Place South, Exhibit Hall A, Poster Section 39, Poster Board Number: 11 Session Category: Experimental and Molecular Therapeutics Session Title: Modulators of Ionizing Radiation and Other Radiotherapeutics Permanent Abstract Number: 848

The poster will be available on 15 April 2018 on the company's website at:

For further information, please contact:

IR enquiries Malene Brondberg, VP Investor Relations and Corporate Communications Cell: +44-7561-431-762 Email:

Media Enquiries Mark Swallow/David Dible/Isabelle Andrews (Citigate Dewe Rogerson) Tel: +44-207-638-9571 Email:

About Nordic Nanovector

Nordic Nanovector is committed to develop and deliver innovative therapies to patients to address major unmet medical needs and advance cancer care. The Company aspires to become a leader in the development of targeted therapies for haematological cancers.

Nordic Nanovector's lead clinical-stage candidate is Betalutin®, a novel CD37-targeting Antibody-Radionuclide-Conjugates (ARC) designed to advance the treatment of non-Hodgkin's Lymphoma (NHL). NHL is an indication with substantial unmet medical need, representing a growing market forecast to be worth nearly USD 20 billion by 2024.

The Company aims to rapidly develop Betalutin®, alone and in combination with other therapies, for the treatment of major types of NHL, targeting first regulatory submission in relapsed/refractory follicular lymphoma in 2019.

Nordic Nanovector intends to retain marketing rights and to actively participate in the commercialisation of Betalutin® in core markets.

The Company is also advancing a pipeline of ARCs and other immunotherapies for multiple cancer indications.

Further information about the Company can be found at

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SOURCE Nordic Nanovector

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