PARAMUS, N.J., May 9, 2018 /PRNewswire/ -- Glenmark Pharmaceuticals, a global pharmaceutical company, today announced newand updated data on GBR 830 will be presented at the upcoming International Investigative Dermatology Meeting (IID) in Orlando, Florida. The IID meeting occurs only once every five years and brings together top researchers
"In the five years since the last IID meeting, our lead dermatology asset, GBR 830, has progressed from an early preclinical asset to one that is now in Phase 2b clinical efficacy trials," said Fred Grossman, President and Chief Medical Officer at Glenmark Pharmaceuticals. "The advancement of GBR 830 marks a major milestone for our company, and is evidence of our rapid transformation into an organization on the leading-edge of innovative research."
The scheduled times (noted in Eastern Time) of the presentations at the Rosen Shingle Creek Resort are as follows:
About GBR 830 in Atopic Dermatitis
GBR 830 is designed to inhibit OX40, a costimulatory immune checkpoint receptor expressed on activated T cells and memory T cells. Costimulatory signals are essential for T cell activity, and binding between OX40 and OX40L is a biomarker for the severity of autoimmune diseases. The activation of this pathway leads to conversion of activated T cells into memory T cells, which promotes inflammation. In addition, regulatory T cells also contribute to inflammation, and OX40 signaling by these cells downregulates immune suppressing functions. It is believed that GBR 830 may inhibit the dual activities of OX40 and OX40L binding in both activated T cells and regulatory T cells, thus potentially reducing inflammation associated with symptoms of atopic dermatitis.
About Glenmark Pharmaceuticals
Glenmark Pharmaceuticals Ltd. (GPL) is a global innovative pharmaceutical company with operations in more than 50 countries. Glenmark has a diverse pipeline with several compounds in various stages of clinical development, primarily focused in the areas of oncology, respiratory disease and dermatology. Glenmark has improved the lives of millions of patients by offering safe, affordable medications for nearly 40 years. For more information, visit glenmarkpharma-us.com.
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SOURCE Glenmark Pharmaceuticals
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