New Study: Pycnogenol(R) Improves Memory in Elderly

Monday, March 17, 2008 General News
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HOBOKEN, N.J., March 17 New research accepted forpublication in the Journal of Psychopharmacology, demonstrates Pycnogenol(R),(pic-noj-en-all), an antioxidant plant extract from the bark of the Frenchmaritime pine tree, improves the memory of senior citizens. The study resultsrevealed Pycnogenol(R) improved both numerical working memory as well asspatial working memory using a computerized testing system. The research waspresented last week at the Oxygen Club of California 2008 World Congress onOxidants and Antioxidants in Biology in Santa Barbara, CA.

"These results support research from a range of disciplines that suggestthat antioxidants may have an effect in preserving or enhancing specificmental functions," said Dr. Con Stough, lead researcher of the study."Cognitive research in this area specifically indicates that the putativebenefits associated with antioxidant supplementation are associated withmemory."

The double-blind, placebo controlled, matched pairs study, which was heldat the Centre for Neuropsychology at Swinburne University, Melbourne Australia, examined the effects of Pycnogenol(R) on a range of cognitive andbiochemical measures in 101 senior individuals aged 60-85 years old. The studyalso examined the 'oxidative stress' hypothesis of ageing and neurologicaldegeneration as it relates to normal changes in cognition in elderlyindividuals. Participant screening for the study included medical history andcognitive assessment. Participants consumed a daily dose of 150mg ofPycnogenol(R) for a three-month treatment period and were assessed at baselinethen at one, two and three months of the treatment. The control andPycnogenol(R) groups were matched by age, sex, BMI, micronutrient intake andintelligence. The cognitive tasks comprised measures of attention, workingmemory, episodic memory and psycho-motor performance.

Blood samples were taken from subjects and after 3 months treatment amarker known as F2-isoprostanes significantly decreased with Pycnogenol(R),but not in the placebo group. F2-isoprostanes develop by oxidation ofunsaturated fatty acids, which are present in particularly high quantities innerve cell membranes. The coincidence of Pycnogenol(R) significantly improvingmemory after three months and the oxidation of nerve membranes beingsignificantly inhibited suggests that the antioxidant activity ofPycnogenol(R) plays a major role for the clinical effects.

According to Dr. Stough, "The antioxidant Pycnogenol(R) had beneficialcognitive and biochemical effects for elderly individuals. Participants in thePycnogenol(R) groups showed improvement relative to the controls with theeffects becoming evident from the second to third months of the Pycnogenol(R)treatment."

Research on Pycnogenol's(R) cognitive function benefits are currentlybeing investigated further. Several recent research studies on Pycnogenol(R)studied the extract's effects on Attention Deficit Disorders including ADD andADHD. Findings published in the Journal of European Child & AdolescentPsychiatry showed Pycnogenol(R) reduced ADHD symptoms such as hyperactivityand improved attention, concentration and motor-visual coordination inchildren with ADHD.

Dr. Con Stough discussed key points of the study in a presentation March13-14 at the Oxygen Club of California 2008 World Congress. For moreinformation please visit,

About Pycnogenol(R)

Pycnogenol(R) is a natural plant extract originating from the bark of themaritime pine that grows along the coast of southwest France and is found tocontain a unique combination of procyanidins, bioflavonoids and organic acids,which offer extensive natural health benefits. The extract has been widelystudied for the past 35 years and has more than 220 published studies andreview articles ensuring safety and efficacy as an ingredient. Today,Pycnogenol(R) is available in

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