New Study By BioTrends Highlights the Risk of TNF-alpha Inhibitors of Losing Patient Share To Alternative Mechanism Agents in the Treatment of Rheumatoid Arthritis

Thursday, May 6, 2010 General News
Email Print This Page Comment bookmark
Font : A-A+

EXTON, Pa., May 6 BioTrends is pleased to announce the publication of a new syndicated report, TreatmentTrendsŪ: Rheumatoid Arthritis. This report covers the use of biologics for the treatment of rheumatoid arthritis (RA). The report, part of a quarterly series, focuses on current and future use of biologic agents, patient market share, perceived strengths and weaknesses of the key brands, barriers to broader usage, sales force performance and perceived value of manufacturers' patient assistance programs.

According to the surveyed respondents (106 rheumatologists), although TNF-alpha inhibitors will continue to dominate the market, the TNF-alpha inhibitors drug class is at risk of losing patient market share to biologics with alternative mechanisms of action such as Actemra, Orencia and Rituxan. Remicade, in particular, is susceptible to losing additional future patient market share to Orencia and Actemra among certain segments of rheumatologists. However, a significant unmet need still exists for an efficacious and fast-acting therapy for TNF-refractory patients. Indeed, the perceptual gap between TNF-alpha inhibitors and Non-TNF-alpha inhibitors with alternative mechanisms of action is currently very wide, based on important attributes which directly influence physician behavior.

During the second quarter of 2009, two new TNF-alpha inhibitors (Simponi and Cimzia) were launched almost simultaneously. Simponi has outperformed Cimzia on several performance metrics with respect to perceptions about product performance, physician trial and usage and aggressiveness of initiation in the RA treatment continuum. Physician receptivity to the recent launch of Actemra, a TNF-alpha inhibitor alternative with an entirely novel mechanism of action (interleukin-6 inhibition), indicates this agent has the potential to fill a significant unmet need among TNF-refractory patients and, in doing so, could potentially alter the current RA treatment paradigm.

The most established injectable TNF-alpha inhibitors (Enbrel and Humira) both significantly outperform other biologics on key efficacy and safety parameters. Although both Enbrel and Humira are at relative parity on efficacy and safety, Enbrel has a competitive advantage over Humira on important attributes that are physician-related in contrast to Humira which holds advantages on patient-related attributes. Regardless, these leading brands are expected to face competition from both the newer, longer-acting TNF-alpha inhibitors as well as alternative mechanism agents in the near future.

About BioTrends Research Group, Inc.

BioTrends Research Group, Inc. ( ) provides syndicated market research to pharmaceutical manufacturers competing in clinically evolving, specialty pharmaceutical markets. For information on BioTrends' publications and research capabilities, please contact us at (610) 363-3872 or BioTrends Research Group, Inc. is a Decision Resources, Inc. company.

About Decision Resources, Inc.

Decision Resources, Inc. is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources, Inc. at

All company, brand, or product names contained in this document may be trademarks or

registered trademarks of their respective holders.

BioTrends Research Group, Inc. Decision Resources, Inc. Sharon Funk Christopher Comfort 404-223-2963 781-296-2597

SOURCE BioTrends Research Group, Inc.

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
I agree to the terms and conditions

News A - Z


News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Press Release Category

Press Release Archive

Stay Connected

  • Available on the Android Market
  • Available on the App Store