SAN FRANCISCO, Oct. 2, 2019 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today announced the acceptance of five clinical and preclinical data abstracts for its immuno-oncology portfolio at the 2019 Society for Immunotherapy of Cancer (SITC) Annual Meeting. The presentations include an oral session with a presentation of updated data from the PIVOT-02 study of bempegaldesleukin
Details of the oral presentation are as follows:
Abstract Title: "Clinical activity, including deepening of response, of BEMPEG plus NIVO in previously untreated patients with metastatic 1L Melanoma: results from the Phase 1/2 PIVOT-02 Study" Abstract: O35 Presenter: Dr. Adi Diab, MD Anderson Cancer Center Session Title: Concurrent Session 310: Combination Phase 1-2 Clinical Trials Date: Saturday, November 9, 2019, 5:15 p.m. – 5:30 p.m. Eastern Standard Time
Details of the poster presentations are as follows:
Abstract P619: "NKTR-255, a polymer-conjugated IL-15 receptor agonist, enhances efficacy of therapeutic monoclonal antibodies with ADCC activity in solid tumor models", Kivimäe, S., et al.Session Date and Time: Friday, November 8th from 7:00 a.m. - 8:00 p.m. Eastern Standard Time
Abstract P623: "Bempegaldesleukin in combination with local radiation and systemic checkpoint blockade induces a robust systemic anti-tumor immunity", Pieper, A., et al.Session Date and Time: Friday, November 8th from 7:00 a.m. - 8:00 p.m. Eastern Standard Time
Abstract P622: "Characterization and comparison of NKTR-255, a polymer-conjugated IL-15 versus IL-15 superagonist", Miyazaki, T., et al.Session Date and Time: Saturday, November 9th from 7:00 a.m. - 8:00 p.m. Eastern Standard Time
Details of the Trials in Progress poster presentation are as follows:
Abstract P387: "A Multicenter, Open-Label, Exploratory Platform Study to Evaluate Biomarkers and Immunotherapy Combinations for the Treatment of Patients with Metastatic Castration-resistant Prostate Cancer (PORTER)", Nissola, L., et al.Session Date and Time: Friday, November 8th from 7:00 a.m. - 8:00 p.m. Eastern Standard Time
About Bempegaldesleukin (NKTR-214)Bempegaldesleukin is designed to stimulate cancer-killing immune cells in the body by targeting CD122 receptors found on the surface of these immune cells. CD122, which is also known as the Interleukin-2 receptor beta subunit, is a key signaling receptor that is known to increase proliferation of these effector T cells.1 In clinical and preclinical studies, treatment with bempegaldesleukin resulted in expansion of these cells and mobilization into the tumor micro-environment.2,3
About NKTR-255NKTR-255 is an IL-15 receptor agonist designed to engage the IL-15 pathway to stimulate and expand natural killer (NK) cells and promote the survival and expansion of central memory CD8+ T cells without inducing suppressive regulatory T cells. Through optimal engagement of the IL-15R?/IL-2R? receptor complex, NKTR-255 enhances formation of long-term immunological memory which may lead to sustained anti-tumor immune response. Native rhIL-15 is rapidly cleared from the body and must be administered frequently and in high doses limiting its utility due to toxicity. NKTR-255 is designed with IL-15 receptor alpha specificity to optimize biological activity and is uniquely engineered to provide optimal exposure and an improved safety profile.
About Nektar Nektar Therapeutics is a research-based, development stage biopharmaceutical company whose mission is to discover and develop innovative medicines to address the unmet medical needs of patients. Our R&D pipeline of new investigational medicines includes treatments for cancer, autoimmune disease and chronic pain. We leverage Nektar's proprietary and proven chemistry platform in the discovery and design of our new therapeutic candidates. Nektar is headquartered in San Francisco, California, with additional operations in Huntsville, Alabama and Hyderabad, India. Further information about the company and its drug development programs and capabilities may be found online at http://www.nektar.com.
For Investors:Vivian Wu of Nektar Therapeutics628-895-0661
For Media:Jodi Sievers of Nektar Therapeutics415-482-5593
Dan Budwick of 1ABdan@1abmedia.com973-271-6085
1 Boyman, J., et al., Nature Reviews Immunology, 2012, 12, 180-190.2 Charych, D., et al., Clin Can Res; 22(3) February 1, 20163 Diab, A., et al., Journal for ImmunoTherapy of Cancer 2016, 4(Suppl 1): P369
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SOURCE Nektar Therapeutics
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