NEW YORK, Nov. 9, 2017 /PRNewswire/ -- How will immunotherapy combination regimens impact the NSCLC treatment landscape?
Read the full report: https://www.reportlinker.com/p05175287The pace of change in NSCLC shows no sign of abating. Developments in immunotherapy continue to take centre stage, particularly in first-line treatment. Merck & Co. have a head
start in this setting with recent approvals for Keytruda; however, BMS, AstraZeneca, Roche and Merck Group/Pfizer still have much to play for. As fist-line treatment options expand, how will patients be selected for specific therapies, what role will combinations play, and how will these impact second-line treatment decisions? Targeted therapies also continue to generate much interest. KOLs weigh in on how data from the ALEX trial of Alecensa, and new product approvals, could shake up the treatment algorithm for ALK-positive NSCLC, as well as developments in EGFR-, BRAF- and ROS1-positive disease. In this report seven US and five EU KOLs offer candid insights on 12 marketed therapies and seven pipeline drugs. Take a tour of the report now: Methodology >Research Objectives >Questions Asked >See the NSCLC therapies covered >Find out who the 7 US and 5 European KOLs are >Sample Pages >Top TakeawaysImmunotherapy has transformed front-line treatment options for NSCLC. How is first-line treatment anticipated to evolve, and what will inform treatment decisions, in the non-driver mutation space? How do KOLs interpret the 21G data and the FDA approval of Merck & Co.'s Keytruda in combination with chemotherapy? Biomarker testing and patient selection are set to become more sophisticated. How will they continue to develop and impact the NSCLC treatment algorithm? How do KOLs rate the potential for AstraZeneca's durvalumab, and other PD1/L1 inhibitors, to be used in the treatment of stage III NSCLC? How are the CheckMate-012 data and the potential for BMS' Opdivo plus ipilimumab to succeed as a first-line treatment viewed? How do KOLs interpret the findings from the ALEX trial and how do they view the future for Roche's Alecensa as a potential first-line therapy for ALK-positive NSCLC? What are the overall prospects for Takeda's Alunbrig and Pfizer's lorlatinib as treatments for ALK-positive NSCLC? Quotes"I think you are going to see the biggest change in first-line metastatic NSCLC. In the last few months it has changed many times and it will continue to change because first line is where it is easiest to show a difference. Combination IOs will take over; IOs with chemotherapy will be there."EU Key Opinion Leader"Patients will be getting NGS testing the vast majority of the time. We will get far more sophisticated about predicting which patients will benefit the most and least with immunotherapy and we'll see how we are using immunotherapy now as the dark ages compared to [in five years' time], like 1975 with chemotherapy." US Key Opinion LeaderSample of therapies coveredMarketed TherapiesKeytruda (pembrolizumab; Merck & Co.) Opdivo (nivolumab; Bristol-Myers Squibb) Tecentriq (atezolizumab; Roche) Tagrisso (osimertinib; AstraZeneca) Xalkori (crizotinib; Pfizer/Merck Group) Zykadia (ceritinib; Novartis) Alecensa (alectinib; Roche) Alunbrig (brigatinib; Takeda) Vargatef (nintedanib; Boehringer Ingelheim) Portrazza (necitumumab; Eli Lilly) Cyramza (ramucirumab; Eli Lilly) Tafinlar/Mekinist (dabrafenib/trametinib; Novartis) Pipeline TherapiesAvelumab (Bavencio; Merck Group/Pfizer) Durvalumab (Imfinzi; AstraZeneca) Ipilimumab (Yervoy; Bristol-Myers Squibb) Dacomitinib (PF-00299804; Pfizer) Lorlatinib (PF-06463922; Pfizer) Ensartinib (X-396; Xcovery) OSE-2101 (Tedopi; OSE Immunotherapeutics) KOLs InterviewedKOLs from North AmericaLaura Q.M. Chow, Associate Professor, Medical Oncology, University of Washington School of Medicine, Seattle Cancer Care Alliance, Seattle, WALeora Horn, Associate Professor of Medicine and Clinical Director, Thoracic Oncology Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TNSaad Khan, Assistant Professor, Medical Oncologist, Southwestern Medical Center, University of Texas, Dallas, TXJose I. Mayordomo, Professor, Medical Oncologist, Division of Medical Oncology, University of Colorado Hospital (UCH), Aurora, COJared Weiss, Associate Professor, University of North Carolina at Chapel Hill, Clinical Research, Thoracic Oncology Program, Chapel Hill, NC
Howard West, Medical Oncologist and Medical Director of the Thoracic Oncology Program, Swedish Cancer Institute, Seattle, WAKOLs from EuropeSiow Ming Lee, Professor of Medical Oncology, University College London, London, UKAntonio Passaro, Medical Oncologist, Division of Thoracic Oncology, European Institute of Oncology, Milan, ItalyMaurice Perol, Professor, Head of Thoracic Oncology, Medical Oncology Department, Léon Bérard Cancer Center, Lyon, FranceDavid Planchard, Associate Professor, Department of Medical Oncology (Thoracic Oncology Group), Gustave-Roussy, Villejuif, FranceAnonymous German KOL, Medical Oncologist at a specialist pulmonary hospital, GermanyOngoing BenefitsThe world of pharma is ever changing and executives must always be up-to-date with new developments that could affect their own products, position and research. That is why FirstWord's guarantee to keep Therapy Trends clients up to date with Update Bulletins offers a real commercial advantage. Update Bulletins include expert insight and analysis based on FirstWord analyst re-engagement with the KOLs after major events such as product approvals, key data releases and major conferences to deliver the most valuable insights with each update. Your Therapy Trends Report purchase entitles you to receive three Update Bulletins, which are published approximately every three months for 12 months following the report's publication date. You will receive a copy of each Update Bulletin once available, which are issued each quarter after the publication date. Read the full report: https://www.reportlinker.com/p05175287
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