Isis Pharmaceuticals to Present a General Corporate Update at Its 2011 Annual Meeting of Stockholders and Open House

The agenda for the meeting is as follows:

2:00 p.m. – 2:15 p.m. Annual Meeting of Stockholders (only for stockholders of record as of April 20, 2011)

2:15 p.m. – 3:00 p.m. Corporate Presentation – Stanley T. Crooke, Isis Chairman and Chief Executive Officer

3:00 p.m. – 5:00 p.m. Poster Presentation