SAN DIEGO, Nov. 28, 2018 /PRNewswire/ -- Hillhurst Biopharmaceuticals, Inc., a biopharmaceutical company focused on developingoral carbon monoxide (CO) therapies, today announced the award of an approximately $2 million Phase 2 Small Business Innovation Research (SBIR) grant from the National Heart, Lung, and Blood Institute (NHLBI). This award
"With this award, the NHLBI enables advancing HBI-002 into the clinic to address a significant unmet need in sickle cell disease," said Andrew Gomperts, Hillhurst's Chief Executive Officer. "We believe our novel approach of targeting dual mechanisms to prevent vaso-occlusive crises, including reducing both sickling and inflammation, holds great promise."
About Sickle cell Disease
Sickle cell disease is a genetic disorder that causes severe vaso-occlusive pain crises and is associated with stroke, heart disease, kidney disease as well as premature death. The sickling of red blood cells and inflammation are interrelated causes of the substantial morbidities and mortality of SCD. Millions of people globally suffer from SCD, including 100,000 people in the U.S. The average life expectancy of SCD patients in the US is only 45 years. At the present time, there are a paucity of FDA approved drugs for SCD and a substantial unmet need.
About HBI-002Hillhurst's lead product, HBI-002, is a proprietary investigational drug product designed to deliver CO orally to enable the therapeutic use of CO, which has been shown to mimic the cytoprotective effects of the heme oxygenase metabolic pathway. HBI-002 is an orally dosed therapeutic enabling acute and chronic use for patients suffering from conditions associated with inflammation and cell death, such as sickle cell disease, kidney transplantation, and acute cerebral injury, among others.
About HillhurstHillhurst is a biopharmaceutical company focused on developing carbon monoxide therapeutics with cytoprotective properties, leveraging the heme oxygenase system. Building on more than fifty years of research into the heme oxygenase enzyme and CO as a therapeutic, Hillhurst has developed HBI-002 to enable the oral delivery of CO to treat conditions associated with inflammation, cell death and oxidative tissue injury.
To learn more about Hillhurst, please visit www.hillhurstbio.com.
View original content:http://www.prnewswire.com/news-releases/hillhurst-biopharmaceuticals-receives-phase-2-sbir-funding-for-clinical-development-of-hbi-002-for-prevention-of-vaso-occlusive-crises-in-sickle-cell-disease-300756264.html
SOURCE Hillhurst Biopharmaceuticals, Inc.
Subscribe to our Free Newsletters!