WOBURN, Mass. and HOBOKEN, N.J., Dec. 18, 2018 /PRNewswire-PRWeb/ -- Ethos Veterinary
An additional and parallel innovation of this metastasis-focused drug development collaboration is the integration of pet dogs with cancer (i.e., comparative oncology). Canine cancer patients will receive state-of-the-art medicines delivered through clinical trials that will precede, and in some cases be conducted in parallel, with human clinical trials. "The essence of the problem in my canine cancer patients is metastasis and subsequent recurrence. These naturally occurring cancers will be investigated using a comparative oncology drug development approach," said Chand Khanna, DVM, PhD, DACVIM (Onc), Chief Science Officer of Ethos Veterinary Health. "Our comparative approach will prioritize studies in osteosarcoma, a highly metastatic bone cancer seen in dogs and humans. Osteosarcoma is very similar in dogs and humans, including the genomics of the cancer, the pattern of disease spread (i.e., metastasis) and the critical interactions between the tumor and the patient's immune system. As a result of the compressed life-span of dogs and the relatively rapid time to cancer progression, effective antimetastatis drugs may be identified more quickly in clinical trials in dogs and used to inform human clinical development."
About Comparative Oncology In the setting of cancer drug development, comparative oncology involves the inclusion of dogs with naturally occurring cancer in clinical trials, where novel or repurposed drugs are tested to answer questions that cannot be answered in conventional animal models of cancer or human clinical trials.
About Osteosarcoma Osteosarcoma is an aggressive cancer of the bone in dogs and human patients and is the most common type of bone cancer in children and teens. Despite successful control of the primary tumor and follow-up chemotherapy, metastasis continues to be the most common cause of mortality for both species. The last 30 years have brought little improvement in survival outcomes for children with osteosarcoma, despite intensification of therapy. Due to lack of improved outcomes, new approaches to therapy are highly needed. Furthermore, if targeted therapeutics are found to prevent metastasis in this human cancer, a strong biological rationale would exist for the evaluation of such a therapy in other human cancers.
About Ethos Veterinary Health Ethos is a veterinary health company with hospitals across the U.S. providing advanced specialty medical care for pets. Our approach includes a focus on transformative science, continuous learning, growth opportunities for team members, and collaboration. For more information, please visit ethosvet.com.
About Ethos Discovery Ethos Discovery is a 501(c)(3) non-profit incubator of scientific innovation that seeks to improve health outcomes in pets and humans with complex medical problems, including cancer. For more information, please visit ethosvet.com.
About Vuja De Sciences Vuja De is a biotechnology startup dedicated to developing cancer metastasis treatments that prevent cancer progression and recurrence. Our initial focus is osteosarcoma. We utilize leading laboratory technologies for metastatic preclinical endpoints in combination with Comparative Oncology to de risk and inform product development and maximize likelihood for successful human oncology clinical trials. We are testing repurposed drugs that have previously been in human clinical trials, as well as novel preclinical drugs. For more information, please visit vujade-life.com.
SOURCE Vuja De Sciences
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