First Baby Through MACS Technology Successfully Born in Mumbai

Thursday, March 9, 2017 General News
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MUMBAI, March 9, 2017 /PRNewswire/ --

Nova IVI Fertility, India's leading chain

of fertility centres, announced the first reported instance of a baby born in Mumbai through an advanced ART (Assisted Reproductive Technology) technique to treat male infertility - Magnetic Activated Cell Sorting (MACS).
Mrs. Geeta (name changed), aged 39 years old, was unable to bear a child for 8 years even after multiple cycles of IUI and IVF. In spite of many trials with various treatments, there was no sign of a desired outcome. On diagnosis, the fertility experts in Nova IVI Fertility found that the sperm count and quality of the husband, Vinay (name changed), was low, which was a hurdle in attaining pregnancy.

Dr. Richa Jagtap, Fertility Consultant, Nova IVI Fertility, Mumbai diagnosed Mr. Vinay for male infertility based on high DNA Fragmentation Index and suggested to opt for MACS, which was a relatively new technology back then. She explains the case saying, "Considering her age and the declining egg reserve due to multiple failures, Geeta was advised IVF/ICSI. The first IVF cycle was again a failure and before the second attempt, we advised a DNA Fragmentation Index (DFI) test for Vinay. MACS procedure for the separation of better sperms was recommended as the DFI was 34%, suggesting poor sperm fertility. The treatment gave positive results and the couple finally had a successful cycle, and now they are the happy parents of a healthy baby."

With immense joy after being successfully treated for male infertility, Vinay and Geeta said, "We consulted many doctors in the city and underwent several IVF cycles. We were left with no hope after multiple attempts to conceive failed. This was going to be the last of our efforts to conceive through IVF and we were planning to adopt a child. Luckily MACS technology came to our rescue. And today, after 8 long years, we are glad to have our first baby with us. I would say the long wait was worth it. We will consider adopting our second child."

Magnetic Activated Cell Sorting (MACS) is a semen preparation technique that isolates healthy sperms from the ones which are on the verge of death (apoptosis). This helps achieve better fertilisation rate, early embryo cleavage, implantation rate and pregnancy rate.

Over the past few years, male infertility has seen a rapid increase among people in Mumbai. Male factor is found in about 40-45% of all infertility cases, and in patients screened at Nova IVI Fertility, male infertility has seen a jump from 45% in earlier times to nearly 66% in 2016. There are various factors that influence men's fertility. It can be due to multifactorial reasons like genetic causes, infection, testicular or pelvic injury or a severe medical condition like diabetes.

Lifestyle factors such as, nutrition, lack of regular exercise, work stress, exposure to environmental pollutants, etc. also play a role in the development of male infertility. Habits like cigarette smoking, illicit drug and alcohol abuse negatively influence fertility in men.

How male fertility check-ups are done 

A male fertility assessment usually starts with a thorough medical history and a semen analysis that examines the count, motility and morphology of sperm in the ejaculate. Further testing is based on the results of the analysis. Men with very low sperm counts, for example, might require hormonal or genetic testing. If no sperm are found in the ejaculate, a testicular biopsy may be necessary.

Couples struggling with infertility should make every effort to find the right help for both partners and go for fertility counselling. Once the diagnosis of infertility is made with the attending Gynaecologist/Andrologist, comprehensive infertility care units are the best options for couples to seek help. There are many treatment options starting from tablets to IUI (injecting washed bolus of sperms directly into the uterus) and IVF-ICSI depending on the cause and severity of the condition. Advanced ART techniques like MACS (Magnetic Activated Cell Sorting) help select better quality sperms for ICSI.

"MACS is recommended in case of sperms having high DNA Fragmentation Index (DFI), poor fertilisation rate in previous IVF-ICSI cycle, repeated miscarriage among others. Factors like smoking, fever, varicocele, stress, etc. are seen to be responsible for the higher level of apoptotic spermatozoa found in the ejaculate. MACS is also advised for patients with more than two failed cycles of IVF with unexpected poor fertilisation and those who have had high DFI. We have used MACS in over 40 cases at our centre and a pregnancy rate of about 66% per embryo transfer is achieved in these cases. We have observed that people are now more open to this technology and there is an increase in the acceptance of MACS in the past 10 months," Dr. Jagtap adds.

MACS is known to be an effective method to treat male infertility and stands tall as a huge relief for many couples as well as fertility experts. Given the steady increase in the number of infertility cases reported in India, such advanced ART techniques like MACS come as a boon to several childless couples in the country.

About Nova IVI Fertility 

Nova IVI Fertility (NIF) is among the largest service providers in the fertility space. NIF aims to bring advanced Assisted Reproductive Technology (ART) to India in partnership with IVI of Spain. The partnership has resulted in a substantial addition to Nova's IVF services and technology, including proprietary software, training and quality management. With IVI's know-how and vast international expertise, NIF brings the same exceptional standard of processes, protocols and policies to India.

In addition to providing core procedures such as IUI, IVF and Andrology services, NIF offers several state-of-the-art technologies such as Vitrification for preserving embryos and eggs, Embryoscope and ERA to find out the timing of the uterus' capacity to accept embryos - all procedures that significantly improve the chances of a pregnancy following IVF-ICSI, even in patients with multiple previous failures. NIF currently operates 18 fertility centres in India (Ahmedabad (2), Bangalore (3), Chennai, Coimbatore, New Delhi (2), Hisar, Hyderabad, Indore, Jalandhar, Kolkata, Mumbai (2), Pune and Surat).

For further information, please visit:



Media Contact: Raghavi R +91-(80)-6768-0615 PR Specialist Nova IVI Fertility

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