European Hematology Association: Overall Survival Benefit of Obinutuzumab Over Rituximab When Combined With Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Comorbidities

Friday, June 15, 2018 Cancer News
Email Print This Page Comment bookmark
Font : A-A+

STOCKHOLM, June 15, 2018 /PRNewswire/ --

Obinutuzumab is a glycoengineered type II anti-CD20 monoclonal antibody

that is able to attack chronic lymphocytic leukemia (CLL) by binding and destroying malignant CLL cells. Rituximab is a non-glycoengineered type I anti-CD20 monoclonal antibody that also binds and kills CLL cells.

     (Logo: http://mma.prnewswire.com/media/622259/EHA_Logo.jpg

)

We conducted a clinical trial in a population of previously untreated patients with CLL and co-existing diseases (CLL11 study). The study included a head-to-head comparison of two chemoimmunotherapies: obinutuzumab (formerly named GA101) plus chlorambucil (G-Clb) versus rituximab and chlorambucil (R-Clb). Previous analyses of the study with median observation times of approx. 20 and 40 months, respectively, demonstrated longer progression-fee survival (PFS; length of time people live without worsening of their disease) for G-Clb when compared with R-Clb.

At the 23rd EHA Congress, we present results of the final analysis of the CLL11 study with a median observation time of approx. 5 years. In this analysis, G-Clb was not just confirmed to be superior to R-Clb with regard to PFS but apparently overall survival (OS, length of time people stay alive), too. Furthermore, the median time to the next treatment (i.e. the time of being therapy-free after having finished the study treatment with G-Clb) was approx. 4.5 years and nearly doubled when compared to R-Clb.

Study findings:

  • Support the use of obinutuzumab plus chlorambucil (G-Clb) as frontline therapy in patients with CLL and co-existing diseases.
  • Suggest obinutuzumab as the preferred anti-CD20 antibody to be used for chlorambucil-based chemoimmunotherapy, but also for future combination regimens for CLL.

Presenter: Dr Valentin Goede Affiliation: University Hospital Cologne, Germany Topic: OVERALL SURVIVAL BENEFIT OF OBINUTUZUMAB OVER RITUXIMAB WHEN COMBINED WITH CHLORAMBUCIL IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND COMORBIDITIES: FINAL SURVIVAL ANALYSIS OF THE CLL11 STUDY

Abstract S151 will be presented by Valentin Goede on Friday, June 15, 16:15-16:30 in Room A1.

Embargo Please note that our embargo policy applies to all selected abstracts in the Press Briefings. For more information check our Congress Media Guidelines here.

Website: http://www.ehaweb.org

SOURCE European Hematology Association



Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
I agree to the terms and conditions

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Press Release Category

Press Release Archive

Stay Connected

  • Available on the Android Market
  • Available on the App Store