Enesi Pharma and Public Health England Enter R&D Collaboration for Novel Needle-Free Solid-Dose Vaccine for Emergent Threat Pathogens

Monday, October 1, 2018 Drug News
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OXFORD, England, October 1, 2018 /PRNewswire/ --

Enesi Pharma, an innovative pharmaceutical

company developing unique injectable solid dose vaccine products, announces it has entered a research and development collaboration with Public Health England (PHE), an executive agency of the UK Government
's Department of Health and Social Care.  

The collaboration is focused on the development and evaluation of a novel solid-dose formulation of a number of PHE's proprietary vaccine candidates including Anthrax recombinant Protective Antigen (rPA) and Crimean-Congo Haemorrhagic Fever (CCHF) for delivery via Enesi Pharma's ImplaVax® needle-free technology.

Pre-clinical testing of a range of ImplaVax enabled vaccines in animal models has evidenced regimen sparing and a reduced time to achieve threshold immunity against comparative conventional liquid vaccines administered using a needle and syringe. Such regimen sparing saves time and money, allowing more patients to be vaccinated more quickly from a fixed available production volume, potentially expanding coverage, preparedness and emergency response.

The current vaccination schedules of many vaccines require multiple doses. An ImplaVax-enabled vaccine therefore has the potential to dramatically enhance vaccination programmes for military and other at-risk personnel as well as providing a rapidly deployable therapeutic option for individuals who have been exposed to the target infectious disease. ImplaVax enabled vaccines also benefit from extended thermal stability making a significant contribution to reducing the end to end cold chain logistical challenges, cost, and will greatly assist in optimising the cost effectiveness of the national strategic stockpile.

David Hipkiss, CEO of Enesi Pharma, commented: 

"We are extremely encouraged by the positive responses we are seeing from institutions and companies to the potential advantages of our ImplaVax solid-dose vaccine platform across the spectrum of infectious diseases and allergies. In entering this new collaboration with Public Health England, we have an opportunity to apply our technology to address serious biological threats that represents a high priority for at-risk personnel and for the wider population. PHE has access to world-leading scientific expertise and resources in this area, and we are excited to be working with them on this project to provide further validation of our innovative approach." 

Prof. Miles Carroll, Head of Research and Deputy Director at Public Health England, added: 

"The threat of emerging infections is an important public health consideration and we are intrigued by the potential for improvements that Enesi's ImplaVax technology could bring to the vaccination process. These improvements could simplify and accelerate the process, while also providing a rapid means of treating exposed individuals. We are very much looking forward to working with Enesi to develop and evaluate a range of solid-dose vaccines."  


Enesi Pharma is an innovative pharmaceutical company developing novel products with potential to transform performance and delivery of vaccines and make a material impact on global healthcare.

The company's primary focus is the development of novel solid dose vaccines against a range of infectious and other select diseases, working in partnership with global companies, government agencies and non-governmental organisations.

Enesi's ImplaVax® formulation and device technologies offer significant potential benefits for patients, care givers, healthcare professionals and payers through enhanced effectiveness, safety, ease of use, reliability and stability, and are supported by a strong patient preference over a standard needle and syringe.

Enesi's experienced leadership team has a proven track record in the successful development and commercialisation of innovative products delivering high value outcomes for all stakeholders.

For more information visit http://www.enesipharma.com or follow Enesi on Twitter at http://www.twitter.com/enesi_pharma


PHE is the leading UK public health research organisation with national and international expertise in providing solutions advice and products to support national and local public health systems. Key focus areas include infectious disease therapeutics, vaccines, diagnostics & R&D, emergency preparedness & response, radiation and chemical protection and wider public health issues such as health improvement and promotion, infant and adult screening, managing a network of public health intelligence observatories and other key public health interventions.


Enesi Pharma 

David Hipkiss, CEO Tel: +44-(0)-7968-707-072 Email: david.hipkiss@enesipharma.com

Mark Swallow, Pip Batty (International Media Enquiries) Citigate Dewe Rogerson Tel: +44-(0)-20-7638-9571 Email: enesipharma@citigatedewerogerson.com Public Health England  phe-pressoffice@phe.gov.uk

SOURCE Enesi Pharma

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