WELLESLEY, Mass., May 16, 2019 /PRNewswire/ -- Global interest in ubiquitin proteasome systems is growing as researchers
Targeted protein degradation, in particular, is renewing optimism in what was once a field full of "garbage proteins," according to the report "Nothing Degrading about Saving Lives: E3 Ligands Recruiting New Drugs."
Major players in the market include Biogen, Eisai, Novartis, Roche, AC Immune and Eli Lilly.
"Although it is obviously exciting that E3 ligases are revived as a drug target in drug discovery, more importantly it brings a possibility to develop drugs against very challenging proteins," notes report author Marianna Tcherpakov. "One very 'difficult' target is tau protein related to Alzheimer's. Solubilizing or degrading protein plaques is not a trivial mission, therefore systems like PROTAC represent an opportunity to overcome disadvantages of previous technologies."
Work by Arvinas to Create a New Class of Drugs
Arvinas is developing a new class of drugs that engages the body's own natural protein disposal system to treat cancers and other difficult diseases. As a potential improvement over traditional small molecule inhibitors, proteolysis-targeting chimera protein degraders are able to degrade disease-causing proteins through the cell's ubiquitin proteasome system, which routinely degrades proteins. This is just one example of companies using targeted protein degradation platforms in drug discovery.
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Nothing Degrading about Saving Lives: E3 Ligands Recruiting New Drugs( PHM192A )Publish Date: Apr 2019
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