Can Treating Sleep Problems Lower Dementia Risk?

Tuesday, July 18, 2017 General News
Email Print This Page Comment bookmark
Font : A-A+

- Sleep disordered breathing may be a modifiable risk factor for Alzheimer's -

LONDON, July 18, 2017 /PRNewswire-USNewswire/ -- Several new research analyses reported at the Alzheimer's Association

International Conference 2017 (AAIC 2017) in London found significant associations between sleep disordered breathing (SDB) and the accumulation of biomarkers for Alzheimer's disease. These findings highlight the idea that SDB is a modifiable factor that may help lower the risk of dementia and possibly slow the progression of dementia where it already exists.

Sleep disordered breathing is characterized by repeated episodes of hypopnea (under breathing) and apnea (not breathing) during sleep. The predominant form of apnea, Obstructive Sleep Apnea, occurs when an individual's upper airway closes partially or fully, but efforts to breath continue. OSA occurs in an estimated 3 in 10 men and 1 in 5 women.

Research reported at AAIC 2017 found:

  • SDB accelerated the accumulation of brain ?-amyloid both in cognitively normal individuals and individuals with mild cognitive impairment (data from the Alzheimer's Disease Neuroimaging Initiative (ADNI)).
  • Obstructive sleep apnea (OSA) was associated with increased brain ?-amyloid deposition, decreased cerebrospinal fluid (CSF) levels of ?-amyloid and increased tau protein levels.

"The Centers for Disease Control and Prevention says more than one third of American adults do not get enough sleep on a regular basis. Clearly this is not good for brain health or overall health," said Dean M. Hartley, PhD, Alzheimer's Association Director of Science Initiatives. "Sleep disordered breathing is treatable in many cases. Through early diagnosis and effective treatment of these sleep disorders, there is the potential to improve cognition and possibly reduce dementia risk. But first we need to know more about the connections between these medical conditions."

Sleep-Disordered Breathing and Obstructive Sleep Apnea Are Associated With Amyloid DepositionThree analyses reported by investigative teams at Wheaton College in Wheaton, Illinois, at AAIC 2017 examined sleep patterns among participants in ADNI to characterize potential effects of SDB and OSA on brain changes associated with mild cognitive impairment and Alzheimer's disease. Amanda Shim and colleagues examined brain ?-amyloid-42 accumulation in a cohort of 516 cognitively normal subjects and found that those with SDB had higher levels in CSF at baseline and more rapid accumulation over time. They found no interactive effect between OSA and the Alzheimer's risk gene APOE-e4. This suggests that OSA may be independently associated with brain amyloid burden.

Megan Hogan and colleagues performed similar analyses to assess the effects of OSA in 798 subjects with mild cognitive impairment (MCI). As with the cognitively normal cohort, both baseline ?-amyloid-42 levels and the rate of accumulation were higher in subjects with OSA. While MCI does not always lead to dementia, a person with MCI is at an increased risk of developing Alzheimer's or another dementia. These results suggest that SDB may be an independent risk factor for Alzheimer's and raises the possibility that interventions aimed at treating SDB may also reduce Alzheimer's risk.

A combined analysis of the cognitively normal and mild cognitive impairment populations, plus a third group with Alzheimer's disease (n=325), evaluated the effects of OSA on levels of several Alzheimer's disease biomarkers in cerebrospinal fluid (CSF) and brain ?-amyloid burden measured by positron emission tomography. Analyses showed:

  • Associations between OSA and CSF A?42 levels in the MCI and Alzheimer's groups.
  • Significant OSA associations were observed with [brain] A?42 levels in CN and MCI participants.
  • OSA subjects experienced faster increase in [brain] A?42 over time in the CN and MCI groups.
  • OSA participants experienced a faster decrease in CSF A?42 and increases in TAU and PTAU volumes over time in both the CN and MCI groups.

According to research team leader, Omonigho Bubu, MD, MPH, these results "highlight the importance of checking for and accurately diagnosing sleep disordered breathing, especially in people at risk for dementia, and more importantly in people diagnosed with MCI, so that it can be addressed and treated."

"If OSA accelerates deposition of beta amyloid in the brain, then it becomes a possible target for therapeutic intervention. More research is needed to confirm these findings," Bubu said.

About the Alzheimer's Association International ConferenceThe Alzheimer's Association International Conference (AAIC) is the world's largest gathering of researchers from around the world focused on Alzheimer's and other dementias. As a part of the Alzheimer's Association's research program, AAIC serves as a catalyst for generating new knowledge about dementia and fostering a vital, collegial research community.AAIC 2017 home page: 2017 newsroom:

About the Alzheimer's AssociationThe Alzheimer's Association is the leading voluntary health organization in Alzheimer's care, support and research. Our mission is to eliminate Alzheimer's disease through the advancement of research, to provide and enhance care and support for all affected, and to reduce the risk of dementia through the promotion of brain health. Our vision is a world without Alzheimer's. Visit or call  +1 800.272.3900.

  • Amanda Shim, et al. Sleep Disordered Breathing, APOE4 and ?-Amyloid Deposition in Cognitive Normal Elderly. (Funder(s): Wheaton College Faculty Development Grant)
  • Megan Hogan, et al. Obstructive Sleep Is Associated with Longitudinal Increases in Amyloid Burden in Elderly Mild Cognitive Impairment Individuals. (Funder(s): Wheaton College Development Grant)
  • Omonigho Bubu, MD, MPH, et al. Effect of Obstructive Sleep Apnea (OSA) on Rate of Change of AD Biomarkers in Cognitive Normal, MCI and AD Elderly: Findings from the Alzheimer's Disease Neuroimaging Initiative (ADNI) Cohort. (Funder(s): Wheaton College Faculty Development Grant)


View original content:

SOURCE Alzheimer's Association

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
I agree to the terms and conditions

News A - Z


News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Press Release Category

Press Release Archive

Stay Connected

  • Available on the Android Market
  • Available on the App Store