CAMBRIDGE, Mass., April 1, 2019 /PRNewswire/ -- BGI Americas today announced the launch of Oseq™ Hereditary
Oseq HCP is a hereditary cancer assay designed to identify known and emerging tumor biomarkers for 17 cancer types. The assay identifies germline variants covered in full exome regions of up to 115 target genes by the MGISEQ-2000 and Illumina HiSeq 2500 and 4000 systems. One unique feature of the Oseq HCP is the comprehensive coverage of BRCA1/2 gene mutations in a proprietary database that is first in China. The database, BGI Hereditary Cancer Genetic Database v1.0, integrates results from more than 30,000 clinical tests and demonstrates a high consistency rate between automated database and manual interpretations as well as a low percentage of Variant of Unknown Significance (VUS) for BRCA1/2 gene mutations.
Inherited genetic mutations play a significant role in 5% to 10% of all cancers. In particular, the germline mutations in BRCA1/2 genes lead to DNA damage repair deficiency and genetic instability of cells. PARP (Poly ADP-Ribose Polymerase) inhibitor (PARPi) potentially exploits DNA damage repair deficiencies such as BRCA mutations to preferentially kill cancer cells. Clinical studies have shown that the first PARPi is highly potent and has a dual mechanism of action to induce tumor cell death by blocking PARP enzyme activity and trapping PARP on the sites of DNA damage.
The clinical utility of Oseq HCP and pharma experience have proved that BGI is uniquely positioned to offer pharma partners a "China solution" in co-developing precision medicine worldwide:
"BGI has a successful track record with the hereditary cancer panel, supporting multiple PARPi clinical trials in China," said Charles Bao, Ph.D., General Manager of BGI Americas. "The past successes have demonstrated our strength and commitment to driving healthcare innovation through the development and global commercialization of precision medicine. I am optimistic that the Oseq hereditary cancer panel will lead to more approvals of anti-cancer drugs."
For additional product and availability information, please visit:
1. Int J Gynecol Cancer 2017; 27: 1650-16572. Lancet Oncol 2017; 18: 1274-12843. N Engl J Med 2017; 377: 523-5334. N Engl J Med 2018; 379: 2495-2505
About BGI AmericasBGI Americas provides comprehensive sequencing and bioinformatics services for basic and translational research as well as pharmaceutical drug development in North, Central and South Americas. We help our customers achieve their research goals by delivering rapid, high-quality results using a broad array of cost-effective, cutting-edge technologies, including our own innovative DNBseq™ sequencing technology. Our customers also benefit from BGI's vast scientific expertise and massive sequencing capacity in state-of-the-art service laboratories, including our CAP/CLIA laboratory in Hong Kong. For more information, visit https://www.bgi.com/us/.
Media Contact Information:
Anthony Tong, Ph.D. BGI Americas +1 617 500 2741 email@example.com
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