WESTFIELD, N.J., Nov. 14, 2018 /PRNewswire/ -- Acquist Therapeutics, Inc., a biopharmaceutical company committed
Acquist has developed novel, potent bifunctional inhibitors that regulate both production and excretion of UA. Prior studies have shown that lowering UA in animals with NASH can halt lipogenesis, inflammation, and disease progression, but the benefit was limited to animals with elevated UA. UA appears to be a central mediator of NASH and may be a causal factor in NASH patients with high serum UA, comprising 30% of patients.
Dr. Warrell commented, "Our data complement earlier work showing striking benefit from lowering UA in NASH animal models. The new data in human liver cells indicate our biomarker-defined approach could benefit a specific subgroup of NASH patients by altering both upstream and downstream activators of lipogenesis and inflammation. However, this targeted approach may require novel drugs like ACQT1127, since conventional agents (i.e., allopurinol, febuxostat, lesinurad, etc.) are associated with liver, renal, and cardiovascular side-effects that suggest unsuitability for NASH patients. Given its high potency and multifunctional targeting, ACQT1127 may make a substantial contribution to the treatment of both gout and NASH."
About NASH and Gout
Acquist targets diseases that share a common characteristic: excessive levels of serum uric acid, which can induce inflammation that leads to progressive illness, deformity, debilitation, and organ failure. In Gout, the Company is developing potentially transformational therapy for an illness that afflicts at least 16 million patients in the U.S./EU and is epidemic in East Asia. Gout patients have excess uric acid that leads to exquisitely painful arthritis, kidney failure, and probably accelerated cardiovascular disease. Fewer than 25% of gout patients respond to standard 1st-line treatment.
In NASH, uric acid promotes accumulation of liver fat, which can trigger inflammation that leads to progressive fibrosis and liver failure. No drugs have been approved for NASH.
Acquist is focused on improving health for patients with inflammatory and metabolic diseases. Simultaneously targeting enzymes that regulate both production and excretion of uric acid, Acquist compounds are markedly more potent than standard monofunctional drugs. Our prototype drug has demonstrated exceptional clinical activity. In NASH and gout, effective treatment could relieve both morbidity and mortality from these progressive illnesses. Further information can be accessed at www.acquistrx.com.
Contacts:Brian M. PinkstonTiberend Strategic Advisorsbpinkston@tiberend.com (212) 375-6298
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SOURCE Acquist Therapeutics, Inc.
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