NEW YORK, Sept. 6, 2018 /PRNewswire-PRWeb/ -- The Job Research Foundation has announced that it will award a pair
The Job Research Foundation seeks to not only help find a cure for Job Syndrome by providing the scientific community with additional opportunities to further research into the rare multisystem immunodeficiency disorder, but also hopes that investigators will research treatments for those suffering with Job Syndrome.
In 2007, Steven M. Holland, M.D., chief of the NIAID Laboratory of Clinical Infectious Diseases, led the research team that over several years assembled the patient group that helped unravel the 41-year-old mystery of the cause of Job Syndrome. A key finding involved work with proteins that alert the body to increase production of white blood cells, increase immune-enhancing chemicals, and increase their killing of invaders. These signal transducer and activator of transcription (STAT) proteins help alert and direct immune system responses to stop invading pathogens. In 48 Job's syndrome patients, Dr. Holland's team sequenced the gene that makes STAT3 protein and discovered that mutations in the gene causes Job's syndrome. (https://www.nih.gov/news-events/news-releases/scientists-identify-cause-jobs-syndrome)
Only about 300 cases of Job's Syndrome have been reported since it was first discovered. Patients often suffer from life-threatening complications from basic infections as the disease makes the immune system extremely sensitive to bacteria. People with the syndrome often have multiple, recurring ailments, such as skin infections that cause lesions and boils, and lung infections that cause pneumonia. The disease was named after the Biblical character Job who suffered from boils.
"Our long-term goal is to help advance research to find a cure for Job Syndrome," said Ted Lavin, co-founder of The Job Research Foundation. "In the short term, we hope the research will improve the treatments for patients suffering from this rare disease. Since announcing the grant opportunity, we have received interest from around the world, including researchers from Harvard, The Cleveland Clinic and Rockefeller University, and are looking forward to reviewing the applications in the fall."
Job Syndrome, also known as Autosomal Dominant Hyperimmunoglobulin E Syndrome (AD-HIES), was discovered in 1966 and is a multisystem immunodeficiency disorder found in males and females worldwide. It can be inherited from either parent or result from a new genetic mutation.
Visit https://www.jobresearchfoundation.org/ for additional details about The Job Syndrome Foundation and for information about the Grant Application Process.
SOURCE Job Research Foundation
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