Commonly used antituberculous drugs
Treatment recommendations for the various forms of tuberculosis
Group-I (Prevention therapy) - 6 months of Isoniazid and Rifampicin.
The consensus statement of the IAP working group is Monotherapy has no
1. Group 1 (Prevention therapy) _ 6HR
a) Asymptomatic Mantoux positive < 3 years
b) Asymptomatic Mantoux positive < 5 years with Grades III, IV PEM
Asymptomatic Mantoux +ve implies that the
patient has no tuberculous lesion and only a tuberculin positivity.
c) Recent converter to Mantoux +ve without signs (Healed lesion: Normal CXR/Calcification/Fibrosis)
d) Children < 3 years of age with history of contact
e) Children < 5 years of age with history of contact with PRIM III & IV
2. Group 2 _ 2 HRZ/4HR
a) Primary complex (Lungs)
b) Symptomatic mantoux +ve < 3 years without localization
c) Symptomatic mantoux +ve < 5 years without localization
with PEM Gr III, IV
d) Isolated lymphadenitis
e) Pleural effusion
3. Group 3 _ 2HRZE/4 HR(extend HR to 7 months if there is no improvement)
a) Progressive pulmonary disease
b) Multiple tuberculous lymphadenitis.
4. Group 4 _ 2HRZE/7HR
a) Miliary / Disseminated TB
b) Bronchopneumonia / cavity
c) Abdominal, pericardial, genitourinary disease, osteoarticular
5.Group 5 _ 2HRZE / 10 HRE
I. Baby born to mother with tuberculosis (Diagnosed in 3rd Trimester)
II. Congenital tuberculosis - 2HRZ/7HR
Sl. No. Name of drug Daily dosage Main adverse effects (mg/kg/d)
01 Isoniazid (H)+ 5 Hepato toxicity
02 Rifampicin ® 10 Hepato toxicity
03 Pyrazinamide (Z) 30 Hepato toxicity
04 Ethambutol (E) 15 Visual disturbance
05 Streptomycin (S) 15 Ototoxicity, Nephro
1. + Newer < 5mg/kg; to be rounded off to the closest higher value
2. All drugs should be administered in a single daily dose on empty stomach
3. Drug is safe, if used in recommended dosage schedule.
4. Vit B6 is not necessary in children on INH.
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