Medications that can Cause Depression
- Antihypertensives (clonidine, propranolol, thiazides, reserpine)
- Nonsteroidal anti-inflammatory agents
Questions should also be directed at the possibility of recreational drug or alcohol
use. Studies suggest that 10% to 30% of alcoholic patients suffer from depression. Ideally, patients who are using mind-altering substances should discontinue them and be reevaluated before antidepressant drug treatment is initiated. In the real world,
this often is impossible, and treatment of depression with a selective serotonin reuptake inhibitor (SSRI) may help promote abstinence from alcohol. Use of tricyclic antidepressants or monoamine oxidase inhibitors should be avoided in this group.