Leukocytosis with Normal Bone Marrow
In most instances, increased white blood cell counts are the result of normal bone marrow reacting to inflammation or infection. Most of these cells are polymorphonuclear leukocytes (PML). Circulating PML and less mature forms (e.g., band cells and metamyelocytes) move to a site of injury or infection. This is followed by the release of stored leukocytes, commonly referred to as a "left shift." Inflammation-associated leukocytosis occurs in tissue necrosis, infarction, burns and arthritis.
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