List of Drugs that may cause Pruritus (Itching)

Acetaminophen and Codeine

Most Common - Drowsiness, lightheadedness, dizziness, slow heartbeat, sedation, shortness of breath, unusual thoughts or behavior, nausea, vomiting, flushing, vision changes, easy bruising or bleeding, stomach pain, loss of appetite, constipation, itching, decrease in platelets in blood, dark urine, clay-colored stools and difficulty in urinating

Agalsidase

Most Common - Chills, fever, feeling hot or cold, difficulty in breathing, nausea, swelling of the face, mouth, and throat, flushing, headache, vomiting, tingling, fatigue, itching, pain in extremity, high blood pressure, chest pain, throat tightness, abdominal pain, dizziness, fast heart rate, nasal congestion, diarrhea, muscle pain, back pain, pallor, slow heart rate, hives, low blood pressure, face swelling, rash, and drowsiness

Alclometasone Dipropionate

Most Common - Chills, fever, feeling hot or cold, difficulty in breathing, nausea, swelling of the face, mouth, and throat, flushing, headache, vomiting, tingling, fatigue, itching, pain in extremity, high blood pressure, chest pain, throat tightness, abdominal pain, dizziness, fast heart rate, nasal congestion, diarrhea, muscle pain, back pain, pallor, slow heart rate, hives, low blood pressure, face swelling, rash, and drowsiness

Ambrisentan

Most Common - Weakness, injection site pain, dizziness, headache, tingling, and itching

Amodiaquine

Most Common - Nausea, vomiting, itching, stomach upset and headache

Anagrelide

Most Common - Headache, palpitations, diarrhea, weakness, fluid retention, nausea, abdominal pain, dizziness, difficulty in breathing, flatulence, vomiting, fever, swelling in the extremities, rash, hives, chest pain, loss of appetite, fast heart rate, inflammation of pharynx, uneasiness, tingling, back pain, itching and indigestion

Anidulafungin

Most Common - Rash, hives, flushing, itching, asthma, difficulty in breathing, and low blood pressure

Apraclonidine

Most Common - Increased blood flow, itching, tearing, discomfort, lid edema, dry mouth, unusual or unpleasant taste in your mouth and foreign body sensation

Aspirin and Oxycodone

Most Common - Increased blood flow, itching, tearing, discomfort, lid edema, dry mouth, unusual or unpleasant taste in your mouth and foreign body sensation

Bezafibrate

Most Common- Gastrointestinal upset, nausea, vomiting, itching, hives, muscle pain, dizziness, hair loss, impotence, fainting, fatigue and increase in liver enzymes

Cetuximab

Most Common - Rash, itching, nail changes, headache, diarrhea and infections

Denileukin Diftitox

Most Common - Fever, nausea, fatigue, rigors, vomiting, diarrhea, headache, swelling in the extremities, cough, difficulty in breathing and itching

Dexmethylphenidate Hcl

Most Common - Fever, nausea, fatigue, rigors, vomiting, diarrhea, headache, swelling in the extremities, cough, difficulty in breathing and itching

Diflorasone Diacetate

Most Common - Burning, itching, irritation, dryness, skin inflammation, pimples, eruptions, low pigmentation, maceration of the skin, secondary infection, scar, stripes or lines

Flunisolide

Most Common- Nasal irritation, itching, increased cough, nausea, vomiting, sore throat, nasal congestion, sneezing, nasal burning, nosebleed and nasal dryness

Fluorouracil

Most Common - Burning, crusting, skin inflammation, erosions, redness of the skin, pigmentation, irritation, pain, photosensitivity, itching, scar, rash, soreness and ulceration

Fondaparinux

Most Common- Mild bleeding, reduced platelet levels, irritation, rash or itching at the injection site

Hydromorphone


Most Common - Light-headedness, dizziness, sedation, nausea, vomiting, increased sweating, flushing, anxiety, dry mouth and itching

Idursulfase


Most Common- Irregular heart beat, blood clot in lungs, blue or purple coloration of the skin, respiratory failure, infection, joint pain, headache, fever, rash, itching, redness, hives and high blood pressure

Influenza Virus Vaccine


Most Common- Irregular heart beat, blood clot in lungs, blue or purple coloration of the skin, respiratory failure, infection, joint pain, headache, fever, rash, itching, redness, hives and high blood pressure

Ipilimumab

Most Common - Fatigue, diarrhea, itching, rash and intestinal inflammation

Mequinol and Tretinoin

Most Common - Redness, burning, stinging, tingling, desquamation, itching, and skin irritation

Mometasone

Cream- Most Common- Burning, flushing, itching, redness, second infection, skin thinning and discoloration, swelling, tingling/stinging, wasting of the skin

Niacin

Most Common - Flushing, diarrhea, nausea, vomiting, increased cough and itching

Nilotinib

Most Common - Rash, itching, headache, nausea, fatigue, muscle pain, upper abdominal pain, hair loss, constipation, diarrhea, dry skin, muscle spasms, joint pain and abdominal pain

Ofloxacin

Most Common - Nausea, headache, sleeplessness, genital itching in women, dizziness, vaginal inflammation, diarrhea and vomiting

Oxymorphone

Most Common- Nausea, constipation, dizziness, vomiting, itching, drowsiness, headache and increased sweat

Palifermin

Most Common- Nausea, constipation, dizziness, vomiting, itching, drowsiness, headache and increased sweat

Polidocanol Injection

Most Common - Local - Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration or warmth

Pralatrexate Solution

Most Common - Decrease in platelet counts and white blood cells, inflammation of mucous, nausea, fatigue, anemia, constipation, fever, fluid retention, cough, nose bleed, vomiting, diarrhea, difficulty in breathing, loss of appetite, rash, itching, throat pain, liver function test abnormal, abdominal pain, pain in extremity, back pain, night sweats, weakness, fast heart rate

Raxibacumab

Most Common- Rash, pain in extremity, itching and drowsiness

Remifentanil

Most Common - Nausea, vomiting, itching, headache, increased sweating, shivering, dizziness, low blood pressure, slow heart rate, respiratory depression, muscle rigidity, chills, flushing, warm sensation

Ropivacaine

Most Common- Low blood pressure, nausea, vomiting, slow heart rate, fever, chills, pain, postoperative complications, stuffy nose, reduced sensation, anemia, tingling, headache, itching and back pain

Sodium Nitroprusside


Most Common - Abdominal pain, apprehension, diaphoresis, dizziness, headache, muscle twitching, nausea, palpitations, restlessness and retching

Sparfloxacin

Most Common - Photosensitivity reaction, diarrhea, nausea, headache, indigestion, dizziness, sleeplessness, abdominal pain, itching, taste perversion, QT interval prolongation, vomiting, flatulence, and dilatation of blood vessels

Sulfasalazine

Most Common - Nausea, indigestion, rash, headache, abdominal pain, vomiting, fever, dizziness, mouth ulcer, itching, abnormal liver function tests, decrease in white blood cells and decrease in platelets

Tramadol

Most Common- Dizziness/vertigo, nausea, constipation, headache, drowsiness, vomiting, itching, CNS stimulation, weakness, sweating, indigestion, dry mouth and diarrhea

Tretinoin

Most Common - Headache, fever, skin dryness, bone pain, nausea/vomiting, rash, itching, increased sweating, visual disturbances, hair loss, skin changes and bone inflammation

Trioxsalen

Most Common- Itching, irritation and nausea

Vemurafenib Tablet

Most Common - Joint pain, rash, hair loss, fatigue, photosensitivity reaction, nausea, itching, and skin papilloma

Verteporfin

Most Common - Fainting, sweating, dizziness, rash, difficulty in breathing, flushing and changes in blood pressure and heart rate, headache, uneasiness, hives, and itching

Zinc Acetate

Most Common- Stomach upset, nausea, vomiting, dry mouth, severe allergic reactions like rash, hives, itching, difficulty in breathing, tightness in the chest and swelling of the mouth, face, lips, or tongue


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