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Medications and their Potential to Cause Increase 'Peripheral Edema' (Swelling In The Extremities)

This section presents medications that are known to potentially lead to 'Peripheral Edema' as a side effect." It's important to note that mild side effects are quite common with medications.
Please be aware that the drugs listed here are individual medications and may be part of a broader combination therapy. This information is meant to be a helpful resource but should not replace professional medical advice. If you're concerned about 'Peripheral Edema', it's best to consult a healthcare professional.
In addition to 'Peripheral Edema', other symptoms or signs might better match your side effect. We have listed these below for your convenience. If you find a symptom that more closely resembles your experience, you can use it to identify potential medications that might be the cause.
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Drugs with the Side Effect - Peripheral Edema

Aliskiren, Amlodipine and Hydrochlorothiazide

Most other Common Side Effects: Swelling in the extremities, dizziness, headache and throat inflammation

Allopurinol

Most other Common Side Effects: Swelling in the extremities, dizziness, headache and throat inflammation
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Ambrisentan

Most other Common Side Effects: Swelling in the extremities, dizziness, headache and throat inflammation

Amlodipine Hydrochlorothiazide and Olmesartan

Most other Common Side Effects: Dizziness, lightheadedness, swelling in the extremities, headache, fatigue, inflammation of the nasopharynx, muscle spasms, nausea, upper respiratory tract infection, diarrhea, urinary tract infection, joint swelling
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Anagrelide

Most other Common Side Effects: Headache, palpitations, diarrhea, weakness, fluid retention, nausea, abdominal pain, dizziness, difficulty in breathing, flatulence, vomiting, fever, swelling in the extremities, rash, hives, chest pain, loss of appetite, fast heart rate, inflammation of pharynx, uneasiness, tingling, back pain, itching and indigestion

Bexarotene

Most other Common Side Effects: Underactive thyroid, headache, weakness, rash, anemia, nausea, infection, swelling in the extremities, abdominal pain, dry skin, diarrhea, fatigue/lethargy, liver function test abnormalities, muscle spasm and confusion

Denileukin Diftitox

Most other Common Side Effects: Fever, nausea, fatigue, rigors, vomiting, diarrhea, headache, swelling in the extremities, cough, difficulty in breathing and itching

Enzalutamide

Most other Common Side Effects: Weakness, fatigue, back pain, diarrhea, joint pain, hot flush, swelling in the extremities, muscle pain, headache, upper respiratory infection, muscle weakness, dizziness, sleeplessness, lower respiratory infection, spinal cord compression, cauda equina syndrome, blood in urine, tingling, anxiety, and high blood pressure

Erythromycin

Most other Common Side Effects: Weakness, fatigue, back pain, diarrhea, joint pain, hot flush, swelling in the extremities, muscle pain, headache, upper respiratory infection, muscle weakness, dizziness, sleeplessness, lower respiratory infection, spinal cord compression, cauda equina syndrome, blood in urine, tingling, anxiety, and high blood pressure

Felodipine

Most other Common Side Effects: Swelling in the extremities and headache

Fluoxetine and Olanzapine

Most other Common Side Effects: Disturbance in attention, dry mouth, fatigue, excessive sleepiness, increased appetite, swelling in the extremities, drowsiness, tremor, blurred vision , and increased weight

Pioglitazone and Metformin

Most other Common Side Effects: Upper respiratory tract infection, diarrhea, swelling in the extremities, and headache

Raloxifene


Most other Common Side Effects: Hot flushes, leg cramps, sweating, sleep disorders, vaginal bleeding; flu-like symptoms, rashes, headache

Sirolimus

Most other Common Side Effects: Swelling in the extremities, high blood pressure, increased cholesterol level, constipation, abdominal pain, diarrhea, headache, fever, urinary tract infection, anemia, nausea, joint pain, and decrease in platelet counts

Sunitinib

Most other Common Side Effects: Fatigue, weakness, fever, diarrhea, nausea, mouth ulcer, vomiting, indigestion, abdominal pain, constipation, high blood pressure, swelling in the extremities, rash, hand-foot syndrome, skin discoloration, dry skin, hair color changes, altered taste, headache, back pain, joint pain, cough, difficulty in breathing, loss of appetite, and bleeding

Tamoxifen

Most other Common Side Effects: Swelling in the extremities, depression, dizziness, lightheadedness, headache, hair thinning and/hair loss and vaginal dryness

Verapamil

Most other Common Side Effects: Constipation, headache, upper respiratory infection, dizziness, fatigue, swelling in the extremities, nausea, elevated liver enzymes, raised alkaline phosphatase, slow heart rate, tingling, flushing and low blood pressure

Find drugs that can cause other symptoms like 'Peripheral Edema'

References
  1. https://www.fda.gov/drugs/information-consumers-and-patients-drugs/finding-and-learning-about-side-effects-adverse-reactions
  2. https://nctr-crs.fda.gov/fdalabel/ui/search
  3. https://dailymed.nlm.nih.gov/dailymed/
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