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Medications and their Potential to Cause Increase 'Itching'(Pruritus)


This section presents medications that are known to potentially lead to 'Itching' as a side effect. It's important to note that mild side effects are quite common with medications.
Please be aware that the drugs listed here are individual medications and may be part of a broader combination therapy. This information is meant to be a helpful resource but should not replace professional medical advice. If you're concerned about 'Itching', it's best to consult a healthcare professional.
In addition to 'Itching', other symptoms or signs might better match your side effect. We have listed these below for your convenience. If you find a symptom that more closely resembles your experience, you can use it to identify potential medications that might be the cause.

Drugs with the Side Effect - Itching

Acetaminophen and Codeine


Most other Common Side Effects: Drowsiness, lightheadedness, dizziness, slow heartbeat, sedation, shortness of breath, unusual thoughts or behavior, nausea, vomiting, flushing, vision changes, easy bruising or bleeding, stomach pain, loss of appetite, constipation, decrease in platelets in blood, dark urine, clay-colored stools and difficulty in urinating

Agalsidase


Most other Common Side Effects: Chills, fever, feeling hot or cold, difficulty in breathing, nausea, swelling of the face, mouth, and throat, flushing, headache, vomiting, tingling, fatigue, pain in extremity, high blood pressure, chest pain, throat tightness, abdominal pain, dizziness, fast heart rate, nasal congestion, diarrhea, muscle pain, back pain, pallor, slow heart rate, hives, low blood pressure, face swelling, rash, and drowsiness

Alclometasone Dipropionate


Most other Common Side Effects: Chills, fever, feeling hot or cold, difficulty in breathing, nausea, swelling of the face, mouth, and throat, flushing, headache, vomiting, tingling, fatigue, pain in extremity, high blood pressure, chest pain, throat tightness, abdominal pain, dizziness, fast heart rate, nasal congestion, diarrhea, muscle pain, back pain, pallor, slow heart rate, hives, low blood pressure, face swelling, rash, and drowsiness

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Alpha One-proteinase inhibitor


Most other Common Side Effects: Weakness, injection site pain, dizziness, headache, tingling

Ambrisentan


Most other Common Side Effects: Weakness, injection site pain, dizziness, headache, tingling

Amodiaquine


Most other Common Side Effects: Nausea, vomiting, stomach upset and headache

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Anagrelide


Most other Common Side Effects: Headache, palpitations, diarrhea, weakness, fluid retention, nausea, abdominal pain, dizziness, difficulty in breathing, flatulence, vomiting, fever, swelling in the extremities, rash, hives, chest pain, loss of appetite, fast heart rate, inflammation of pharynx, uneasiness, tingling, back pain

Anidulafungin


Most other Common Side Effects: Rash, hives, flushing, asthma, difficulty in breathing, and low blood pressure

Apraclonidine


Most other Common Side Effects: Increased blood flow, tearing, discomfort, lid edema, dry mouth, unusual or unpleasant taste in your mouth and foreign body sensation

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Aspirin and Oxycodone


Most other Common Side Effects: Increased blood flow, tearing, discomfort, lid edema, dry mouth, unusual or unpleasant taste in your mouth and foreign body sensation

Bezafibrate


Most other Common Side Effects: Gastrointestinal upset, nausea, vomiting, hives, muscle pain, dizziness, hair loss, impotence, fainting, fatigue and increase in liver enzymes

Cetuximab


Most other Common Side Effects: Rash, nail changes, headache, diarrhea and infections

Denileukin Diftitox


Most other Common Side Effects: Fever, nausea, fatigue, rigors, vomiting, diarrhea, headache, swelling in the extremities, cough

Dexmethylphenidate Hcl


Most other Common Side Effects: Fever, nausea, fatigue, rigors, vomiting, diarrhea, headache, swelling in the extremities, cough

Diflorasone Diacetate


Most other Common Side Effects: Burning, irritation, dryness, skin inflammation, pimples, eruptions, low pigmentation, maceration of the skin, secondary infection, scar, stripes or lines

Diltiazem


Most other Common Side Effects: Burning, irritation, dryness, skin inflammation, pimples, eruptions, low pigmentation, maceration of the skin, secondary infection, scar, stripes or lines

Flunisolide


Most other Common Side Effects: Nasal irritation, increased cough, nausea, vomiting, sore throat, nasal congestion, sneezing, nasal burning, nosebleed and nasal dryness

Fluorouracil


Most other Common Side Effects: Burning, crusting, skin inflammation, erosions, redness of the skin, pigmentation, irritation, pain, photosensitivity, scar, rash, soreness and ulceration

Fondaparinux


Most other Common Side Effects: Mild bleeding, reduced platelet levels, irritation

Human Papillomavirus Quadrivalent


Most other Common Side Effects: Fever, nausea, dizziness, injection-site pain, swelling, redness, and bruising

Hydromorphone



Most other Common Side Effects: Light-headedness, dizziness, sedation, nausea, vomiting, increased sweating, flushing, anxiety

Idursulfase



Most other Common Side Effects: Irregular heart beat, blood clot in lungs, blue or purple coloration of the skin, respiratory failure, infection, joint pain, headache, fever, rash, redness, hives and high blood pressure

Influenza Virus Vaccine



Most other Common Side Effects: Irregular heart beat, blood clot in lungs, blue or purple coloration of the skin, respiratory failure, infection, joint pain, headache, fever, rash, redness, hives and high blood pressure

Ipilimumab


Most other Common Side Effects: Fatigue, diarrhea, rash and intestinal inflammation

Mequinol and Tretinoin


Most other Common Side Effects: Redness, burning, stinging, tingling, desquamation, and skin irritation

Mometasone


Cream- Most other Common Side Effects: Burning, flushing, redness, second infection, skin thinning and discoloration, swelling, tingling/stinging, wasting of the skin

Niacin


Most other Common Side Effects: Flushing, diarrhea, nausea, vomiting

Nilotinib


Most other Common Side Effects: Rash, headache, nausea, fatigue, muscle pain, upper abdominal pain, hair loss, constipation, diarrhea, dry skin, muscle spasms, joint pain and abdominal pain

Ofloxacin


Most other Common Side Effects: Nausea, headache, sleeplessness, dizziness, vaginal inflammation, diarrhea and vomiting

Oxymorphone


Most other Common Side Effects: Nausea, constipation, dizziness, vomiting, drowsiness, headache and increased sweat

Palifermin


Most other Common Side Effects: Nausea, constipation, dizziness, vomiting, drowsiness, headache and increased sweat

Podofilox Topical Solution


Most other Common Side Effects: Burning, pain, inflammation, erosion

Polidocanol Injection


Most other Common Side Effects: Local - Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration or warmth

Pralatrexate Solution


Most other Common Side Effects: Decrease in platelet counts and white blood cells, inflammation of mucous, nausea, fatigue, anemia, constipation, fever, fluid retention, cough, nose bleed, vomiting, diarrhea, difficulty in breathing, loss of appetite, rash, throat pain, liver function test abnormal, abdominal pain, pain in extremity, back pain, night sweats, weakness, fast heart rate

Raxibacumab


Most other Common Side Effects: Rash, pain in extremity

Remifentanil


Most other Common Side Effects: Nausea, vomiting, headache, increased sweating, shivering, dizziness, low blood pressure, slow heart rate, respiratory depression, muscle rigidity, chills, flushing, warm sensation

Ropivacaine


Most other Common Side Effects: Low blood pressure, nausea, vomiting, slow heart rate, fever, chills, pain, postoperative complications, stuffy nose, reduced sensation, anemia, tingling, headache

Sodium Nitroprusside



Most other Common Side Effects: Abdominal pain, apprehension, diaphoresis, dizziness, headache, nausea, palpitations, restlessness and retching

Sparfloxacin


Most other Common Side Effects: Photosensitivity reaction, diarrhea, nausea, headache, indigestion, dizziness, sleeplessness, abdominal pain, taste perversion, QT interval prolongation, vomiting, flatulence, and dilatation of blood vessels

Sulfasalazine


Most other Common Side Effects: Nausea, indigestion, rash, headache, abdominal pain, vomiting, fever, dizziness, mouth ulcer, abnormal liver function tests, decrease in white blood cells and decrease in platelets

Tramadol


Most other Common Side Effects: Dizziness/vertigo, nausea, constipation, headache, drowsiness, vomiting, CNS stimulation, weakness, sweating, indigestion, dry mouth and diarrhea

Tretinoin


Most other Common Side Effects: Headache, fever, skin dryness, bone pain, nausea/vomiting, rash, increased sweating, visual disturbances, hair loss, skin changes and bone inflammation

Trioxsalen


Most other Common Side Effects: irritation and nausea

Vemurafenib Tablet


Most other Common Side Effects: Joint pain, rash, hair loss, fatigue, photosensitivity reaction, nausea, and skin papilloma

Verteporfin


Most other Common Side Effects: Fainting, sweating, dizziness, rash, difficulty in breathing, flushing and changes in blood pressure and heart rate, headache, uneasiness, hives

Zinc Acetate


Most other Common Side Effects: Stomach upset, nausea, vomiting, dry mouth, severe allergic reactions like rash, hives, difficulty in breathing, tightness in the chest and swelling of the mouth, face, lips, or tongue

References

  1. https://www.fda.gov/drugs/information-consumers-and-patients-drugs/finding-and-learning-about-side-effects-adverse-reactions
  2. https://nctr-crs.fda.gov/fdalabel/ui/search
  3. https://dailymed.nlm.nih.gov/dailymed/
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