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Side effect(s) of Tegafur and Uracil


Review the side-effects of Tegafur and Uracil as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.

If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.

  Gastrointestinal:
Diarrhea, nausea, vomiting, stomatitis, stomach pain, loss of appetite

  Nervous system:
Nerve pain, neuropathy, burning or prickling sensation in the hands and feet, speech disturbances

  Cardiovascular:
Blood clots, heart attack, chest pain

  Skin:
Hair loss, rashes, itching, eczema, leukoderma

  Others:
Bone marrow suppression, weakness, anemia, abnormal values of white blood cells and platelets, liver damage, loss of control in balance

Other Precautions :

The treatment with tegafur-uracil can be stopped temporarily and resumed once the side effects are significantly reduced and the abnormal blood cell counts return to near normal limits.

Treatment discontinuation of tegafur-uracil is usually not recommended because most of the side effects are reversible when the dose of tegafur-uracil is reduced or withheld.

Wash the skin or flush the eyes thoroughly with clean water if the capsule contents of tegafur-uracil come into contact with the skin or eyes.

There are no specific antidotes available for treating an overdose of tegafur-uracil. So, patients with such episodes must be treated appropriately for the symptoms and signs along with supportive care under the supervision of a toxicologist or a specialist.

Drug Name : Tegafur and Uracil

Tegafur and uracil combination is used as a first-line treatment along with calcium folinate to treat colorectal cancer that has moved to other body parts in adult patients. It is also known as UFT or UFUR.


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