Piperazine generic Piperazine citrate is used as a second-line treatment for treating roundworm infections caused by Ascaris lumbricoides and pinworm infections caused by Enterobius vermicularis (oxyuris). It paralyses the worm which is then expelled by the digestive tract. Although it is highly active against Ascaris and Enterobius, it is not commonly used because of its repeated doses while other anthelmintics offer single dose treatment.
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