Review the side-effects of Panobinostat as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. Gastrointestinal: Diarrhea, fatigue, nausea, peripheral edema (accumulation of water), decreased appetite, and vomiting.
Hematological: low platelet count), low white blood cell count, anemia (low Hemoglobin), low phosphorous, potassium levels in the blood.
Nervous system: dizziness, headache , syncope (fainting), dysgeusia (altered taste)
Cardiovascular: palpitations (increased heart rate)
Respiratory: cough , dyspnea, respiratory failure, wheezing (abnormal lung sounds)
Vascular system: hypotension (low blood pressure), hypertension (High blood pressure)
Skin and subcutaneous disorders: skin rash, erythema (redness of skin)
Musculoskeletal disorders: joint swelling.
Renal and urinary disorders: Kidney failure, urinary incontinence (uncontrolled leak of urine)
General disorders and administration site conditions: chills.
Lab monitoring: blood urea, glomerular filtration rate, blood alkaline phosphatase levels should be monitored.
• Men should use condoms for at least 3 months of the last dose of panobinostat.
• Panobinostat capsules contact with the skin or mucous membranes should be avoided. Wash thoroughly if such contact occurs.
• Exposure to crushed and/or broken capsules should be avoided.
• Keep away from children.
• Patients should report chest pain or discomfort or changes in heartbeat, fever, swelling in legs, hands and skin, diarrhea, bleeding, immediately to consulting doctor.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. Gastrointestinal: Diarrhea, fatigue, nausea, peripheral edema (accumulation of water), decreased appetite, and vomiting.
Hematological: low platelet count), low white blood cell count, anemia (low Hemoglobin), low phosphorous, potassium levels in the blood.
Nervous system: dizziness, headache , syncope (fainting), dysgeusia (altered taste)
Cardiovascular: palpitations (increased heart rate)
Respiratory: cough , dyspnea, respiratory failure, wheezing (abnormal lung sounds)
Vascular system: hypotension (low blood pressure), hypertension (High blood pressure)
Skin and subcutaneous disorders: skin rash, erythema (redness of skin)
Musculoskeletal disorders: joint swelling.
Renal and urinary disorders: Kidney failure, urinary incontinence (uncontrolled leak of urine)
General disorders and administration site conditions: chills.
Lab monitoring: blood urea, glomerular filtration rate, blood alkaline phosphatase levels should be monitored.
Other Precautions :
• Women in reproductive age should use effective contraception until 1 month of the last dose of panobinostat.• Men should use condoms for at least 3 months of the last dose of panobinostat.
• Panobinostat capsules contact with the skin or mucous membranes should be avoided. Wash thoroughly if such contact occurs.
• Exposure to crushed and/or broken capsules should be avoided.
• Keep away from children.
• Patients should report chest pain or discomfort or changes in heartbeat, fever, swelling in legs, hands and skin, diarrhea, bleeding, immediately to consulting doctor.
