Read the side effects of Midostaurin as described in the medical literature. In case of any doubt consult your doctor or pharmacist.
Common: Nausea, vomiting, neutropenia (low white blood cell counts), edema (fluid accumulation), fatigue, fever
Gastrointestinal: Inflammation of the mucous membranes,
piles, raised pancreatic enzymes, abdominal discomfort or pain, constipation, bleeding
Cardiovascular: Prolonged QT interval (an abnormality in the electrical activity of the heart), fluctuations in blood pressure, heart attack, pericardial effusion (fluid accumulation around the heart), clot formation in a blood vessel
Central nervous system: Headache, dizziness, vertigo, insomnia, difficulty in attention, tremor
Blood: Low blood counts
Respiratory: Nasopharyngitis, sinusitis, bleeding from the nose, difficulty in breathing, lung inflammation, pleural effusion (fluid accumulation around the lung), cough, pain in the oropharynx, upper respiratory tract infection, lung toxicity
Skin: Skin lesions in the form of petechiae, maculopapular rash, erythema multiforme, and erysipelas increased sweating, dry skin
Others: Swelling of eyelids, herpes virus infection, increased levels of creatinine, joint pain, raised levels of uric acid in blood, muscle pain, high blood glucose levels, device-related infections, increase weight, high blood calcium levels, fever
Other Precautions : • Pregnancy test has to be performed within seven days starting the midostaurin treatment and the drug should be initiated only if the pregnancy test is negative.
• Midostaurin may impair fertility in both men and women of childbearing age. It is advised to consider the option of using a sperm or
egg bank to store sperms or eggs before starting treatment.
• The use of midostaurin capsules in pediatric patients is not recommended as the safety and effectiveness of the drug has not established in this group.
