Review the side-effects of Larotrectinib as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. 1.General: Fatigue, swelling of lower legs or hands, fever
2.Gastrointestinal: Nausea, vomiting, constipation, diarrhea, abdominal pain
3.Nervous system: Dizziness, headache
4.Respiratory: Cough, nasal congestion, shortness of breath
5. Vascular: Hypertension
6.Muscles and Joints: Back pain, joint pain, muscle pain, pain in the extremities, muscle weakness.
7. Miscellaneous: Weight gain, Anemia, Decreased appetite, Infertility in females.
2.Neurological adverse effects like gait disturbances, dizziness, tremors, delirium, memory impairment can be seen.
3.Patients are advised not to operate heavy machines if they experience these adverse effects.
4. In females who are able to get pregnant, proper contraceptives should be used during the treatment and one week after the last dose is given.
5. In males with female partners who are able to pregnant, proper contraceptives should be used during the treatment and one week after the last dose is given.
6.Patients should inform their doctors about all the medications they take including herbal medications, OTC products, and vitamin supplements.
7.Do not eat grapefruit or drink grapefruit juice.
Do not take St John Wort.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. 1.General: Fatigue, swelling of lower legs or hands, fever
2.Gastrointestinal: Nausea, vomiting, constipation, diarrhea, abdominal pain
3.Nervous system: Dizziness, headache
4.Respiratory: Cough, nasal congestion, shortness of breath
5. Vascular: Hypertension
6.Muscles and Joints: Back pain, joint pain, muscle pain, pain in the extremities, muscle weakness.
7. Miscellaneous: Weight gain, Anemia, Decreased appetite, Infertility in females.
Other Precautions :
1.Monitor liver function tests every two weeks during the first month and after that monthly. Reduce the starting dose of larotrectinib in patients with moderate liver function impairment.2.Neurological adverse effects like gait disturbances, dizziness, tremors, delirium, memory impairment can be seen.
3.Patients are advised not to operate heavy machines if they experience these adverse effects.
4. In females who are able to get pregnant, proper contraceptives should be used during the treatment and one week after the last dose is given.
5. In males with female partners who are able to pregnant, proper contraceptives should be used during the treatment and one week after the last dose is given.
6.Patients should inform their doctors about all the medications they take including herbal medications, OTC products, and vitamin supplements.
7.Do not eat grapefruit or drink grapefruit juice.
Do not take St John Wort.
