Review the side-effects of Dabrafenib as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.
Gastrointestinal: Constipation, nausea, vomiting, swelling of the pancreas, loss of appetite, bleeding in stomach or intestine
Nervous system: Headache, dizziness, abnormal weakness
Respiratory: Coughing up blood, sore throat, runny nose or the common cold, breathing difficulty, chest pain
Musculoskeletal: Muscle pain, back pain, pain in the joints
Skin: Rashes, hair loss, abnormal thickening of the skin, new warts, red skin, skin peeling, skin tags
Lab abnormalities: High blood sugar levels, low levels of sodium and phosphate in blood, increased levels of alkaline phosphatase
Others: Fever, chills, eye pain, swelling of eyelids, heart disease, swelling of kidneys, sensitivity to light
• Never take hormonal contraceptives as these effects are greatly affected by dabrafenib capsules.
• Inform the doctor immediately when the patient gets pregnant or a pregnancy is suspected during dabrafenib treatment.
• Breastfeeding should be stopped during dabrafenib therapy and for at least two weeks after stopping dabrafenib capsules as it is harmful to the baby.
• Dabrafenib can affect the fertility status; therefore patients who have plans for pregnancy must be advised to prepare for sperm or egg banking for future use before starting the treatment with dabrafenib.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.
Gastrointestinal: Constipation, nausea, vomiting, swelling of the pancreas, loss of appetite, bleeding in stomach or intestine
Nervous system: Headache, dizziness, abnormal weakness
Respiratory: Coughing up blood, sore throat, runny nose or the common cold, breathing difficulty, chest pain
Musculoskeletal: Muscle pain, back pain, pain in the joints
Skin: Rashes, hair loss, abnormal thickening of the skin, new warts, red skin, skin peeling, skin tags
Lab abnormalities: High blood sugar levels, low levels of sodium and phosphate in blood, increased levels of alkaline phosphatase
Others: Fever, chills, eye pain, swelling of eyelids, heart disease, swelling of kidneys, sensitivity to light
Other Precautions :
• Women of childbearing age should take effective non-hormonal contraception during dabrafenib treatment that should be continued for at least two weeks after taking the last dose of dabrafenib.• Never take hormonal contraceptives as these effects are greatly affected by dabrafenib capsules.
• Inform the doctor immediately when the patient gets pregnant or a pregnancy is suspected during dabrafenib treatment.
• Breastfeeding should be stopped during dabrafenib therapy and for at least two weeks after stopping dabrafenib capsules as it is harmful to the baby.
• Dabrafenib can affect the fertility status; therefore patients who have plans for pregnancy must be advised to prepare for sperm or egg banking for future use before starting the treatment with dabrafenib.
