Chloroquine(Aralen) generic Chloroquine is used for the treatment of Malaria, Rheumatoid Arthritis, Lupus Erythematosus & COVID-19 Infection. Mechanism of action: It acts by blocking the action of enzyme ‘heme polymerase’ in malarial parasites and this leads to accumulation of heme - which is toxic to the malarial parasite. This leads to the death of the malarial parasite. Update: •FDA warns against the use of chloroquine or hydroxychloroquine for treating COVID-19 outside the hospital setting or a clinical trial due to high risk of heart rhythm issues. • Chloroquine and hydroxychloroquine gained attention in spite of sayings by the World Health Organization (WHO) that there is no definitive evidence they work for COVID-19 patients. • Larger, high-quality randomized clinical trials may be needed in order to precisely evaluate its effectiveness, according to University of Oxford's Kome Gbinigie, author of a report on anti-malarial testing for Covid-19. • More than 20 trials are being carried out on chloroquine for treating COVID-19 in the US, UK, Spain, and China.
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