Review the side-effects of Cephaloridine as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. • Cefaloridine has marked dose-related nephrotoxicity.
• The drug accumulates in the proximal renal tubular cell, probably by active anionic transport.
• Probenecid, which blocks such transport, is given to patients to eliminate the nephrotoxicity of cephaloridine when it occurs.
• Other side effects common to first-generation cephalosporin class of antibiotics are
Diarrhea, nausea, rash, pain and inflammation at the injection site
Gastrointestinal: Pseudomembranous colitis (inflammation of the colon)
Hematological disorders: Esinophilia, low levels of prothrombin, abnormalities of blood coagulation
Nephrological disorder: Renal damage at large doses
Others: Vomiting, headache, dizziness, fungal infections of the mouth and vagina, fever
• Certain complications that maybe caused by the use of cephaloridine include seizures, coma, chronic renal failure, acute renal failure and death.
• There have been instances of renal tubular necrosis with uremia and death after large doses in some patients with progressive renal disease, and toxic effects on the central nervous system after intrathecal administration.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. • Cefaloridine has marked dose-related nephrotoxicity.
• The drug accumulates in the proximal renal tubular cell, probably by active anionic transport.
• Probenecid, which blocks such transport, is given to patients to eliminate the nephrotoxicity of cephaloridine when it occurs.
• Other side effects common to first-generation cephalosporin class of antibiotics are
Diarrhea, nausea, rash, pain and inflammation at the injection site
Gastrointestinal: Pseudomembranous colitis (inflammation of the colon)
Hematological disorders: Esinophilia, low levels of prothrombin, abnormalities of blood coagulation
Nephrological disorder: Renal damage at large doses
Others: Vomiting, headache, dizziness, fungal infections of the mouth and vagina, fever
• Certain complications that maybe caused by the use of cephaloridine include seizures, coma, chronic renal failure, acute renal failure and death.
Other Precautions :
• The entire course of this antibiotic should be completed even if the patients feel better; this will make sure the infection is cured.• There have been instances of renal tubular necrosis with uremia and death after large doses in some patients with progressive renal disease, and toxic effects on the central nervous system after intrathecal administration.
