Side effect(s) of Cephaloridine

Read the side effects of Cephaloridine as described in the medical literature. In case of any doubt consult your doctor or pharmacist.
• Cefaloridine has marked dose-related nephrotoxicity.

• The drug accumulates in the proximal renal tubular cell, probably by active anionic transport.

Probenecid, which blocks such transport, is given to patients to eliminate the nephrotoxicity of cephaloridine when it occurs.



• Other side effects common to first-generation cephalosporin class of antibiotics are

Diarrhea, nausea, rash, pain and inflammation at the injection site



Gastrointestinal: Pseudomembranous colitis (inflammation of the colon)

Hematological disorders: Esinophilia, low levels of prothrombin, abnormalities of blood coagulation

Nephrological disorder: Renal damage at large doses

Others: Vomiting, headache, dizziness, fungal infections of the mouth and vagina, fever



• Certain complications that maybe caused by the use of cephaloridine include seizures, coma, chronic renal failure, acute renal failure and death.

Other Precautions : • The entire course of this antibiotic should be completed even if the patients feel better; this will make sure the infection is cured.
• There have been instances of renal tubular necrosis with uremia and death after large doses in some patients with progressive renal disease, and toxic effects on the central nervous system after intrathecal administration.
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