Burosumab-twza generic Burosumab-twza or KRN23 is a monoclonal antibody prescribed to treat a rare hereditary disorder called X-linked hypophosphatemia (low levels of phosphate in the blood) in adult and pediatric patients who are one year and above. It has been successfully tested in children with X-linked hypophosphatemic rickets Use of burosumab-twza can be confirmed by the radiographic evidence of bone disease. Burosumab-twza works by blocking the activity of FGF23 protein resulting in reabsorption of phosphate by the kidneys and thereby restoring the phosphate levels in the blood.
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