Review the side-effects of Brigatinib as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.
Common: Nausea, diarrhea , fatigue or tiredness, headache, cough
Gastrointestinal: Constipation , pain in the abdomen, vomiting, loss of appetite, raised levels of the pancreatic enzymes amylase and lipase
Cardiovascular: Decreased heartrate, prolonged activated partial thromboplastin time, high blood pressure
Central nervous system: Lack of sleep, peripheral neuropathy, headache
Respiratory: Difficulty in breathing, cough, interstitial lung disease/pneumonitis, pneumonia
Musculoskeletal: Muscle pain, back pain, joint pain, pain in the extremity
Skin: Exfoliative rashes, itching, pustular rashes, acneiform dermatitis
Eyes: Blurred vision, double vision, reduced visual acuity
Others: Anemia, lymphopenia, fever, urosepsis, increased level of liver enzymes, increase in creatinine phosphokinase, high blood glucose levels, fever, allergic reaction
• It is necessary to advise patients to report to their physician if they experience unusual muscle pain or muscle tenderness or weakness.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.
Common: Nausea, diarrhea , fatigue or tiredness, headache, cough
Gastrointestinal: Constipation , pain in the abdomen, vomiting, loss of appetite, raised levels of the pancreatic enzymes amylase and lipase
Cardiovascular: Decreased heartrate, prolonged activated partial thromboplastin time, high blood pressure
Central nervous system: Lack of sleep, peripheral neuropathy, headache
Respiratory: Difficulty in breathing, cough, interstitial lung disease/pneumonitis, pneumonia
Musculoskeletal: Muscle pain, back pain, joint pain, pain in the extremity
Skin: Exfoliative rashes, itching, pustular rashes, acneiform dermatitis
Eyes: Blurred vision, double vision, reduced visual acuity
Others: Anemia, lymphopenia, fever, urosepsis, increased level of liver enzymes, increase in creatinine phosphokinase, high blood glucose levels, fever, allergic reaction
Other Precautions :
• Women of child-bearing age should be advised to use non-hormonal birth control methods for at least 4 months and men are advised to use a condom for at least 3 months after the last dose of brigatinib. Brigatinib treatment may be associated with infertility.• It is necessary to advise patients to report to their physician if they experience unusual muscle pain or muscle tenderness or weakness.
